TY - JOUR
T1 - SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy
AU - Fukumura, Kazuhiro
AU - Venables, Julian P.
AU - Mayeda, Akila
N1 - Publisher Copyright:
© 2021 Taylor & Francis Group, LLC.
PY - 2021
Y1 - 2021
N2 - The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resistance to various anticancer drugs, SPF45-dependent splicing may play a critical role in multidrug resistance.
AB - The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resistance to various anticancer drugs, SPF45-dependent splicing may play a critical role in multidrug resistance.
UR - http://www.scopus.com/inward/record.url?scp=85119346861&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85119346861&partnerID=8YFLogxK
U2 - 10.1080/23723556.2021.1996318
DO - 10.1080/23723556.2021.1996318
M3 - Comment/debate
AN - SCOPUS:85119346861
SN - 2372-3556
VL - 8
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
IS - 6
M1 - 1996318
ER -
