SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy

Kazuhiro Fukumura, Julian P. Venables, Akila Mayeda

Research output: Contribution to journalComment/debatepeer-review

Abstract

The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resistance to various anticancer drugs, SPF45-dependent splicing may play a critical role in multidrug resistance.

Original languageEnglish
Article number1996318
JournalMolecular and Cellular Oncology
Volume8
Issue number6
DOIs
Publication statusPublished - 2021

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cancer Research

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