SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy

Kazuhiro Fukumura; Julian P. Venables; Akila Mayeda

doi:10.1080/23723556.2021.1996318

SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy

Kazuhiro Fukumura
, Julian P. Venables
, Akila Mayeda

visiting faculty

Research output: Contribution to journal › Comment/debate › peer-review

5 Citations (Scopus)

Abstract

The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resistance to various anticancer drugs, SPF45-dependent splicing may play a critical role in multidrug resistance.

Original language	English
Article number	1996318
Journal	Molecular and Cellular Oncology
Volume	8
Issue number	6
DOIs	https://doi.org/10.1080/23723556.2021.1996318
Publication status	Published - 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Molecular Medicine
Cancer Research

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10.1080/23723556.2021.1996318

Cite this

@article{18a68a7b96c24024b3578d0cb8ccfaa2,

title = "SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy",

abstract = "The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resistance to various anticancer drugs, SPF45-dependent splicing may play a critical role in multidrug resistance.",

author = "Kazuhiro Fukumura and Venables, \{Julian P.\} and Akila Mayeda",

note = "Publisher Copyright: {\textcopyright} 2021 Taylor \& Francis Group, LLC.",

year = "2021",

doi = "10.1080/23723556.2021.1996318",

language = "English",

volume = "8",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

publisher = "Taylor and Francis Ltd.",

number = "6",

}

TY - JOUR

T1 - SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy

AU - Fukumura, Kazuhiro

AU - Venables, Julian P.

AU - Mayeda, Akila

PY - 2021

Y1 - 2021

N2 - The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resistance to various anticancer drugs, SPF45-dependent splicing may play a critical role in multidrug resistance.

AB - The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resistance to various anticancer drugs, SPF45-dependent splicing may play a critical role in multidrug resistance.

UR - https://www.scopus.com/pages/publications/85119346861

UR - https://www.scopus.com/pages/publications/85119346861#tab=citedBy

U2 - 10.1080/23723556.2021.1996318

DO - 10.1080/23723556.2021.1996318

M3 - Comment/debate

AN - SCOPUS:85119346861

SN - 2372-3556

VL - 8

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 6

M1 - 1996318

ER -

SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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