Spinal cord injury or spinal anesthesia eliminates seizures in myelin-deficient rats

J. Rosenbluth; M. Hasegawa

doi:10.1016/0304-3940(88)90339-4

Spinal cord injury or spinal anesthesia eliminates seizures in myelin-deficient rats

J. Rosenbluth, M. Hasegawa

Neurosurgery

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The generalized tonic seizures that occur in myelin-deficient rats can be eliminated temporarily by spinal cord injury or spinal anesthesia. These observations imply that the seizures in this mutant can be triggered by activity in the spinal cord. The results are consistent with an earlier proposal that axons in myelin-deficient CNS fiber tracts can interact to produce abnormal excitation.

Original language	English
Pages (from-to)	68-72
Number of pages	5
Journal	Neuroscience Letters
Volume	84
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(88)90339-4
Publication status	Published - 11-01-1988

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/0304-3940(88)90339-4

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abstract = "The generalized tonic seizures that occur in myelin-deficient rats can be eliminated temporarily by spinal cord injury or spinal anesthesia. These observations imply that the seizures in this mutant can be triggered by activity in the spinal cord. The results are consistent with an earlier proposal that axons in myelin-deficient CNS fiber tracts can interact to produce abnormal excitation.",

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AB - The generalized tonic seizures that occur in myelin-deficient rats can be eliminated temporarily by spinal cord injury or spinal anesthesia. These observations imply that the seizures in this mutant can be triggered by activity in the spinal cord. The results are consistent with an earlier proposal that axons in myelin-deficient CNS fiber tracts can interact to produce abnormal excitation.

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Spinal cord injury or spinal anesthesia eliminates seizures in myelin-deficient rats

Abstract

All Science Journal Classification (ASJC) codes

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