Splenial Lesions in Benign Convulsions With Gastroenteritis Associated With Rotavirus Infection

Chikako Ogawa, Hiroyuki Kidokoro, Naoko Ishihara, Takeshi Tsuji, Hirokazu Kurahashi, Ayako Hattori, Motomasa Suzuki, Shunsuke Ogaya, Yuji Ito, Tatsuya Fukasawa, Tetsuo Kubota, Akihisa Okumura, Shinji Saitoh, Jun Natsume

Research output: Contribution to journalArticle

Abstract

Objective: To investigate clinical risk factors for acute magnetic resonance imaging (MRI) abnormalities in patients with benign convulsions with mild gastroenteritis or benign infantile epilepsy. Study design: We investigated clinical and diffusion-weighted imaging findings in 32 patients with benign convulsions with mild gastroenteritis and 22 patients with benign infantile epilepsy who underwent MRI within seven days of seizure onset between 2010 and 2015. Results: Diffusion-weighted imaging showed signal hyperintensity in the splenium of the corpus callosum in seven patients with benign convulsions with mild gastroenteritis, but no abnormalities in patients with benign infantile epilepsy. Patients with benign convulsions with mild gastroenteritis with splenial lesions showed a higher rate of rotavirus detection from feces (P = 0.006), higher serum level of C-reactive protein (P = 0.04), and shorter interval between seizure onset and MRI (P = 0.002) than patients with benign convulsions with mild gastroenteritis without splenial lesions. Multivariate analysis revealed rotavirus infection as a significant risk factor for splenial lesions on diffusion-weighted imaging in patients with benign convulsions with mild gastroenteritis (P = 0.02). Conclusions: Splenial lesions are often seen during acute period in patients with benign convulsions with mild gastroenteritis. Rotavirus infection is a risk factor for splenial lesions in patients with benign convulsions with mild gastroenteritis, suggesting the role of rotavirus to cause edema in the corpus callosum. From our observations, benign convulsions with mild gastroenteritis with a splenial lesion on diffusion-weighted imaging suggests good outcomes, and extensive evaluation of these patients may be unnecessary.

Original languageEnglish
JournalPediatric Neurology
DOIs
Publication statusAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

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    Ogawa, C., Kidokoro, H., Ishihara, N., Tsuji, T., Kurahashi, H., Hattori, A., Suzuki, M., Ogaya, S., Ito, Y., Fukasawa, T., Kubota, T., Okumura, A., Saitoh, S., & Natsume, J. (Accepted/In press). Splenial Lesions in Benign Convulsions With Gastroenteritis Associated With Rotavirus Infection. Pediatric Neurology. https://doi.org/10.1016/j.pediatrneurol.2019.05.002