Spontaneous healing of rectal penetration by SpaceOAR® hydrogel insertion during permanent iodine-125 implant brachytherapy: A case report

Koji Iinuma; Kosuke Mizutani; Taku Kato; Keita Nakane; Hidekazu Tanaka; Masahiro Nakano; Masayuki Matsuo; Takuya Koie

doi:10.3892/mco.2019.1937

Spontaneous healing of rectal penetration by SpaceOAR^® hydrogel insertion during permanent iodine-125 implant brachytherapy: A case report

Koji Iinuma
, Kosuke Mizutani
, Taku Kato
, Keita Nakane
, Hidekazu Tanaka
, Masahiro Nakano
, Masayuki Matsuo
, Takuya Koie

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Radiation therapy with permanent iodine-125 implant brachytherapy is well established for curable prostate cancer. To maximize the therapeutic potential of brachytherapy, delivered radiation doses have been increased accompanied by refined intraoperative procedures of radioactive seeds placement. However, dose escalation is a double-edged sword in prostate brachytherapy; it could induce rectal toxicity, yet is successful in curable treatment in prostate cancer. To reduce irradiation of the rectum, the SpaceOAR^® system has been used to inject synthetic polyethylene glycol hydrogel between the prostate and the rectum. The present report describes a case of spontaneous healing of rectal penetration associated with SpaceOAR^® hydrogel.

Original language	English
Pages (from-to)	580-582
Number of pages	3
Journal	Molecular and Clinical Oncology
Volume	11
Issue number	6
DOIs	https://doi.org/10.3892/mco.2019.1937
Publication status	Published - 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Access to Document

10.3892/mco.2019.1937

Cite this

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title = "Spontaneous healing of rectal penetration by SpaceOAR{\textregistered} hydrogel insertion during permanent iodine-125 implant brachytherapy: A case report",

abstract = "Radiation therapy with permanent iodine-125 implant brachytherapy is well established for curable prostate cancer. To maximize the therapeutic potential of brachytherapy, delivered radiation doses have been increased accompanied by refined intraoperative procedures of radioactive seeds placement. However, dose escalation is a double-edged sword in prostate brachytherapy; it could induce rectal toxicity, yet is successful in curable treatment in prostate cancer. To reduce irradiation of the rectum, the SpaceOAR{\textregistered} system has been used to inject synthetic polyethylene glycol hydrogel between the prostate and the rectum. The present report describes a case of spontaneous healing of rectal penetration associated with SpaceOAR{\textregistered} hydrogel.",

author = "Koji Iinuma and Kosuke Mizutani and Taku Kato and Keita Nakane and Hidekazu Tanaka and Masahiro Nakano and Masayuki Matsuo and Takuya Koie",

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T2 - A case report

AU - Iinuma, Koji

AU - Mizutani, Kosuke

AU - Kato, Taku

AU - Nakane, Keita

AU - Tanaka, Hidekazu

AU - Nakano, Masahiro

AU - Matsuo, Masayuki

AU - Koie, Takuya

PY - 2019

Y1 - 2019

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AB - Radiation therapy with permanent iodine-125 implant brachytherapy is well established for curable prostate cancer. To maximize the therapeutic potential of brachytherapy, delivered radiation doses have been increased accompanied by refined intraoperative procedures of radioactive seeds placement. However, dose escalation is a double-edged sword in prostate brachytherapy; it could induce rectal toxicity, yet is successful in curable treatment in prostate cancer. To reduce irradiation of the rectum, the SpaceOAR® system has been used to inject synthetic polyethylene glycol hydrogel between the prostate and the rectum. The present report describes a case of spontaneous healing of rectal penetration associated with SpaceOAR® hydrogel.

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