TY - JOUR
T1 - Spontaneous regeneration of the pyramidal tract after transection in young rats
AU - Inoue, Tatsushi
AU - Kawaguchi, Saburo
AU - Kurisu, Kaoru
N1 - Funding Information:
We thank Ms. Ayako Sakamoto for her expertise in Holzer staining. This study was supported by Grant-in-Aid 08271217 for Scientific Research on priority areas from the Ministry of Education, Science, Sports and Culture of Japan, JSPS-RFTF96100203 for the Japan Society for the Promotion of Science, Special Coordination Funds for Promoting Science and Technology, STA, Japan, Health Science Research Grant, and the Uehara Memorial Foundation.
PY - 1998/5/15
Y1 - 1998/5/15
N2 - Spontaneous regeneration of the pyramidal tract after transection of the medullary pyramid was examined in young rats by the anterograde tracing method with wheat germ agglutinin-conjugated horseradish peroxidase. Care was taken to cut the tract as sharply as possible to minimize traumatic injuries. A very sharp cut produced edema-free lesions without subsequent formation of either cysts or scars, whereas a relatively blunt cut produced edema and later scars and/or cysts in the lesion. Regenerated projections in the latter cases were sparse, short, dispersed and largely aberrant as described in previous reports. By contrast, regenerated projections in the former cases were very much similar to normal in various respects: the amount, extension, path, formation of a compact bundle and termination. There was, however, a decisive difference from normal, that is, the additional aberrant projections.
AB - Spontaneous regeneration of the pyramidal tract after transection of the medullary pyramid was examined in young rats by the anterograde tracing method with wheat germ agglutinin-conjugated horseradish peroxidase. Care was taken to cut the tract as sharply as possible to minimize traumatic injuries. A very sharp cut produced edema-free lesions without subsequent formation of either cysts or scars, whereas a relatively blunt cut produced edema and later scars and/or cysts in the lesion. Regenerated projections in the latter cases were sparse, short, dispersed and largely aberrant as described in previous reports. By contrast, regenerated projections in the former cases were very much similar to normal in various respects: the amount, extension, path, formation of a compact bundle and termination. There was, however, a decisive difference from normal, that is, the additional aberrant projections.
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U2 - 10.1016/S0304-3940(98)00297-3
DO - 10.1016/S0304-3940(98)00297-3
M3 - Article
C2 - 9655615
AN - SCOPUS:0032524610
SN - 0304-3940
VL - 247
SP - 151
EP - 154
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2-3
ER -