Spread of varicella-zoster virus DNA to the environment from varicella patients who were treated with oral acyclovir

Kyoko Suzuki, Tetsushi Yoshikawa, Masaru Ihira, Masahiro Ohashi, Sadao Suga, Yoshizo Asano

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: The purpose of the present study was to determine the degree of spread of varicella-zoster virus to the environment (VZV) from varicella patients who received oral acyclovir treatment. Methods: Over a period of 8 months, seven healthy children (two girls and five boys, 23-64 months of age) with varicella who visited Fujita Health University School of Medicine were treated with routine doses of oral acyclovir (ACV) for 5 days, commencing within 24 h after onset of the disease. Swab samples from the throats of patients and their family members as well as from air purifier filters in their houses were collected for 7 days as frequently as possible after starting treatment for the disease. The VZV DNA in the samples was identified by a sensitive polymerase chain reaction amplification assay. Results: The VZV DNA was detected in 33-100% of throat swab samples from varicella patients by day 7 of the disease, in 17-32% of throat swab samples from family members by day 4 and in 29% of filters from air purifiers by day 3. Conclusions: The results suggest a broad spread of VZV, probably by the airborne route, from the patients with varicella even after the administration of oral ACV.

Original languageEnglish
Pages (from-to)458-460
Number of pages3
JournalPediatrics International
Volume45
Issue number4
DOIs
Publication statusPublished - 01-08-2003

Fingerprint

Human Herpesvirus 3
Acyclovir
Chickenpox
Air Filters
Pharynx
DNA
School Health Services
Oral Administration
Medicine
Polymerase Chain Reaction
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

@article{209b150681c0421fa6bfe88c681c40ea,
title = "Spread of varicella-zoster virus DNA to the environment from varicella patients who were treated with oral acyclovir",
abstract = "Objective: The purpose of the present study was to determine the degree of spread of varicella-zoster virus to the environment (VZV) from varicella patients who received oral acyclovir treatment. Methods: Over a period of 8 months, seven healthy children (two girls and five boys, 23-64 months of age) with varicella who visited Fujita Health University School of Medicine were treated with routine doses of oral acyclovir (ACV) for 5 days, commencing within 24 h after onset of the disease. Swab samples from the throats of patients and their family members as well as from air purifier filters in their houses were collected for 7 days as frequently as possible after starting treatment for the disease. The VZV DNA in the samples was identified by a sensitive polymerase chain reaction amplification assay. Results: The VZV DNA was detected in 33-100{\%} of throat swab samples from varicella patients by day 7 of the disease, in 17-32{\%} of throat swab samples from family members by day 4 and in 29{\%} of filters from air purifiers by day 3. Conclusions: The results suggest a broad spread of VZV, probably by the airborne route, from the patients with varicella even after the administration of oral ACV.",
author = "Kyoko Suzuki and Tetsushi Yoshikawa and Masaru Ihira and Masahiro Ohashi and Sadao Suga and Yoshizo Asano",
year = "2003",
month = "8",
day = "1",
doi = "10.1046/j.1442-200X.2003.01746.x",
language = "English",
volume = "45",
pages = "458--460",
journal = "Pediatrics International",
issn = "1328-8067",
publisher = "Wiley-Blackwell",
number = "4",

}

Spread of varicella-zoster virus DNA to the environment from varicella patients who were treated with oral acyclovir. / Suzuki, Kyoko; Yoshikawa, Tetsushi; Ihira, Masaru; Ohashi, Masahiro; Suga, Sadao; Asano, Yoshizo.

In: Pediatrics International, Vol. 45, No. 4, 01.08.2003, p. 458-460.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Spread of varicella-zoster virus DNA to the environment from varicella patients who were treated with oral acyclovir

AU - Suzuki, Kyoko

AU - Yoshikawa, Tetsushi

AU - Ihira, Masaru

AU - Ohashi, Masahiro

AU - Suga, Sadao

AU - Asano, Yoshizo

PY - 2003/8/1

Y1 - 2003/8/1

N2 - Objective: The purpose of the present study was to determine the degree of spread of varicella-zoster virus to the environment (VZV) from varicella patients who received oral acyclovir treatment. Methods: Over a period of 8 months, seven healthy children (two girls and five boys, 23-64 months of age) with varicella who visited Fujita Health University School of Medicine were treated with routine doses of oral acyclovir (ACV) for 5 days, commencing within 24 h after onset of the disease. Swab samples from the throats of patients and their family members as well as from air purifier filters in their houses were collected for 7 days as frequently as possible after starting treatment for the disease. The VZV DNA in the samples was identified by a sensitive polymerase chain reaction amplification assay. Results: The VZV DNA was detected in 33-100% of throat swab samples from varicella patients by day 7 of the disease, in 17-32% of throat swab samples from family members by day 4 and in 29% of filters from air purifiers by day 3. Conclusions: The results suggest a broad spread of VZV, probably by the airborne route, from the patients with varicella even after the administration of oral ACV.

AB - Objective: The purpose of the present study was to determine the degree of spread of varicella-zoster virus to the environment (VZV) from varicella patients who received oral acyclovir treatment. Methods: Over a period of 8 months, seven healthy children (two girls and five boys, 23-64 months of age) with varicella who visited Fujita Health University School of Medicine were treated with routine doses of oral acyclovir (ACV) for 5 days, commencing within 24 h after onset of the disease. Swab samples from the throats of patients and their family members as well as from air purifier filters in their houses were collected for 7 days as frequently as possible after starting treatment for the disease. The VZV DNA in the samples was identified by a sensitive polymerase chain reaction amplification assay. Results: The VZV DNA was detected in 33-100% of throat swab samples from varicella patients by day 7 of the disease, in 17-32% of throat swab samples from family members by day 4 and in 29% of filters from air purifiers by day 3. Conclusions: The results suggest a broad spread of VZV, probably by the airborne route, from the patients with varicella even after the administration of oral ACV.

UR - http://www.scopus.com/inward/record.url?scp=0141742648&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141742648&partnerID=8YFLogxK

U2 - 10.1046/j.1442-200X.2003.01746.x

DO - 10.1046/j.1442-200X.2003.01746.x

M3 - Article

VL - 45

SP - 458

EP - 460

JO - Pediatrics International

JF - Pediatrics International

SN - 1328-8067

IS - 4

ER -