Squamous cell carcinoma arising within oral florid papillomatosis; A report of two cases

Makoto Urano, Shigenobu Iwata, Kensei Naito, Kazuo Sakurai, Shigeki Mori, Yoshihiro Iwata, Katsuhiko Komori, Makoto Kuroda

Research output: Contribution to journalArticlepeer-review


We treated two patients with oral florid papillomatosis (OFF) of the buccal mucosa, which developed into squamous cell carcinoma during a long term follow-up period. The first is a 62-year-old female who developed to squamous cell carcinoma 13 years after OFF, and the second is a 65-year-old female who developed it after 9 years. Both were resistant to laser surgery, irradiation, and chemotherapy, and had agressive local infiltration. In the second case, autopsy revealed generalized métastases. The clinical and pathological characteristics of OFF were tendency of frequent local recurrence, resistance to treatment, and broad papillary proliferation in the basal layer of the epithelium. A review of the literature and a discussion of the histopathological features and treatment of OFF are also presented in this paper.

Original languageEnglish
Pages (from-to)955-961
Number of pages7
JournalPractica Otologica
Issue number8
Publication statusPublished - 1996

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology


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