TY - JOUR
T1 - Standardization of regional reference for mamushi (Gloydius blomhoffii) antivenom in Japan, Korea, and China
AU - Fukuda, Tadashi
AU - Iwaki, Masaaki
AU - Hong, Seung Hwa
AU - Oh, Ho Jung
AU - Wei, Zhu
AU - Morokuma, Kazunori
AU - Ohkuma, Kunio
AU - Dianliang, Lei
AU - Arakawa, Yoshichika
AU - Takahashi, Motohide
PY - 2006
Y1 - 2006
N2 - The mamushi (Gloydius blomhoffii) snakes that inhabit Japan, Korea, and China produce venoms with similar serological characters to each other. Individual domestic standard mamushi antivenoms have been used for national quality control (potency testing) of mamushi antivenom products in these countries, because of the lack of an international standard material authorized by the World Health Organization. This precludes comparison of the results of product potency testing among countries. We established a regional reference antivenom for these three Asian countries. This collaborative study indicated that the regional reference mamushi antivenom has an anti-lethal titer of 33,000 U/vial and anti-hemorrhagic titer of 36,000 U/vial. This reference can be used routinely for quality control, including national control of mamushi antivenom products.
AB - The mamushi (Gloydius blomhoffii) snakes that inhabit Japan, Korea, and China produce venoms with similar serological characters to each other. Individual domestic standard mamushi antivenoms have been used for national quality control (potency testing) of mamushi antivenom products in these countries, because of the lack of an international standard material authorized by the World Health Organization. This precludes comparison of the results of product potency testing among countries. We established a regional reference antivenom for these three Asian countries. This collaborative study indicated that the regional reference mamushi antivenom has an anti-lethal titer of 33,000 U/vial and anti-hemorrhagic titer of 36,000 U/vial. This reference can be used routinely for quality control, including national control of mamushi antivenom products.
UR - https://www.scopus.com/pages/publications/33644541148
UR - https://www.scopus.com/inward/citedby.url?scp=33644541148&partnerID=8YFLogxK
U2 - 10.7883/yoken.jjid.2006.20
DO - 10.7883/yoken.jjid.2006.20
M3 - Article
C2 - 16495629
AN - SCOPUS:33644541148
SN - 1344-6304
VL - 59
SP - 20
EP - 24
JO - Japanese journal of infectious diseases
JF - Japanese journal of infectious diseases
IS - 1
ER -
