Staurosporine, a protein kinase inhibitor, attenuates basal forebrain-lesion-induced amnesia and cholinergic neuronal deficit

Toshitaka Nabeshima, Shin ichi Ogawa, Hidenao Nishimura, Kazuyuki Fuji, Tsutomu Kameyama, Yasuharu Sasaki

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We have investigated whether administration of staurosporine, which has been reported to induce differentiation in the human neuroblastoma cell in vitro, attenuates amnesia induced by basal forebrain lesion in rats. Multiple dosage of staurosporine at the doses of 0.05 and 0.1 mg/kg (i.p.) attenuated the impaired performance of the water maze task. Moreover, staurosporine (0.1 mg/kg) reversed the decrease of choline acetyltransferase activity in the fronto-parietal cortex. These results suggest that staurosporine attenuates amnesia through reversal of deficits in cholinergic neurons induced by basal forebrain lesion, and that neurotrophic factor-like substances may open the way for novel therapeutic approaches to Alzheimer's disease.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalNeuroscience Letters
Volume122
Issue number1
DOIs
Publication statusPublished - 14-01-1991
Externally publishedYes

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Amnesia
Staurosporine
Protein Kinase Inhibitors
Cholinergic Agents
Parietal Lobe
Cholinergic Neurons
Choline O-Acetyltransferase
Nerve Growth Factors
Neuroblastoma
Alzheimer Disease
Basal Forebrain
Water
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Nabeshima, Toshitaka ; Ogawa, Shin ichi ; Nishimura, Hidenao ; Fuji, Kazuyuki ; Kameyama, Tsutomu ; Sasaki, Yasuharu. / Staurosporine, a protein kinase inhibitor, attenuates basal forebrain-lesion-induced amnesia and cholinergic neuronal deficit. In: Neuroscience Letters. 1991 ; Vol. 122, No. 1. pp. 13-16.
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Staurosporine, a protein kinase inhibitor, attenuates basal forebrain-lesion-induced amnesia and cholinergic neuronal deficit. / Nabeshima, Toshitaka; Ogawa, Shin ichi; Nishimura, Hidenao; Fuji, Kazuyuki; Kameyama, Tsutomu; Sasaki, Yasuharu.

In: Neuroscience Letters, Vol. 122, No. 1, 14.01.1991, p. 13-16.

Research output: Contribution to journalArticle

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