Staurosporine, a protein kinase inhibitor, attenuates basal forebrain-lesion-induced amnesia and cholinergic neuronal deficit

Toshitaka Nabeshima, Shin ichi Ogawa, Hidenao Nishimura, Kazuyuki Fuji, Tsutomu Kameyama, Yasuharu Sasaki

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We have investigated whether administration of staurosporine, which has been reported to induce differentiation in the human neuroblastoma cell in vitro, attenuates amnesia induced by basal forebrain lesion in rats. Multiple dosage of staurosporine at the doses of 0.05 and 0.1 mg/kg (i.p.) attenuated the impaired performance of the water maze task. Moreover, staurosporine (0.1 mg/kg) reversed the decrease of choline acetyltransferase activity in the fronto-parietal cortex. These results suggest that staurosporine attenuates amnesia through reversal of deficits in cholinergic neurons induced by basal forebrain lesion, and that neurotrophic factor-like substances may open the way for novel therapeutic approaches to Alzheimer's disease.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 14-01-1991
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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