TY - JOUR
T1 - Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa
AU - Komori, Shiori
AU - Ueno, Shinji
AU - Ito, Yasuki
AU - Sayo, Akira
AU - Meinert, Monika
AU - Kominami, Taro
AU - Inooka, Daiki
AU - Kitagawa, Masahiro
AU - Nishida, Kazuki
AU - Takahashi, Kunihiko
AU - Matsui, Shigeyuki
AU - Terasak, Hiroko
N1 - Publisher Copyright:
© 2019 The Authors. All Rights Reserved.
PY - 2019/7
Y1 - 2019/7
N2 - PURPOSE. A posterior staphyloma has been reported to be present in some eyes with retinitis pigmentosa (RP), and the purpose of this study was to determine the macular curvature of non-highly myopic RP eyes. METHODS. This was a retrospective, observational study. The medical charts of the right eyes of 143 patients with RP and 60 controls whose axial length ranged from 21.5 mm to 26.0 mm were reviewed. The mean curvature of Bruch’s membrane within 6 mm of the central macula obtained from the horizontal optical coherence tomographic images were evaluated as the mean macular curvature index (MMCI). The relationships between the MMCI and other clinical factors were assessed. RESULTS. The mean MMCI of RP patients (13.73 6 9.63 3 10−5 lm−1) was significantly lower than that of the controls (−6.63 6 5.63 3 10−5 lm−1). This indicated a deeper concave shape of the macula in RP eyes (P < 0.001). The MMCI was significantly correlated with the age (r = 0.20; P=0.016) and the axial length (r −0.24; P 0.004). Further analysis suggested a nonlinear effect of the ellipsoid zone width on the macular curvature in the RP eyes. CONCLUSIONS. There is a high incidence of steeper macular curvatures even in non-highly myopic RP eyes, and the steepness was also affected by the degree of photoreceptor degeneration.
AB - PURPOSE. A posterior staphyloma has been reported to be present in some eyes with retinitis pigmentosa (RP), and the purpose of this study was to determine the macular curvature of non-highly myopic RP eyes. METHODS. This was a retrospective, observational study. The medical charts of the right eyes of 143 patients with RP and 60 controls whose axial length ranged from 21.5 mm to 26.0 mm were reviewed. The mean curvature of Bruch’s membrane within 6 mm of the central macula obtained from the horizontal optical coherence tomographic images were evaluated as the mean macular curvature index (MMCI). The relationships between the MMCI and other clinical factors were assessed. RESULTS. The mean MMCI of RP patients (13.73 6 9.63 3 10−5 lm−1) was significantly lower than that of the controls (−6.63 6 5.63 3 10−5 lm−1). This indicated a deeper concave shape of the macula in RP eyes (P < 0.001). The MMCI was significantly correlated with the age (r = 0.20; P=0.016) and the axial length (r −0.24; P 0.004). Further analysis suggested a nonlinear effect of the ellipsoid zone width on the macular curvature in the RP eyes. CONCLUSIONS. There is a high incidence of steeper macular curvatures even in non-highly myopic RP eyes, and the steepness was also affected by the degree of photoreceptor degeneration.
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U2 - 10.1167/iovs.19-27334
DO - 10.1167/iovs.19-27334
M3 - Article
C2 - 31335951
AN - SCOPUS:85070449531
SN - 0146-0404
VL - 60
SP - 3135
EP - 3141
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 8
ER -