Stress-induced behavioral responses and multiple opioid systems in the brain

Kiyofumi Yamada, Toshitaka Nabeshima

Research output: Contribution to journalReview article

113 Citations (Scopus)

Abstract

Various stressor produce a wide range of behavioral responses such as analgesia, catalepsy and motor suppression, which are sensitive to opioid receptor antagonists. These behavioral responses in stress are accompanied by changes in the contents of opioid peptides, the mRNAs encoding their precursors and opioid receptor binding in the brain. In the present article, experimental data concerning stress-induced analgesia and motor suppression is reviewed and discussed in relation to a possible involvement of different opioid systems in the various observed behavioral responses in stress. Pharmacological studies with subtype-selective antagonists have demonstrated that not only μ- but also δ- and/or κ-opioid receptors are involved in opioid-mediated stress-induced analgesia. There are two types of stress-induced analgesia referred to as opioid-mediated and non-opioid mediated forms. It has been proposed that the intensity and temporal pattern of stressor may be a critical factor determining the nature of stress-induced analgesia. Accumulated evidence demonstrate that these two foms of pain inhibitory systems interact each other according to a collateral inhibition model. Recent studies show that parallel activation of multiple opioid receptors mediates non-opioid forms of stress-induced analgesia. Dynorphins, by acting at κ-opioid receptors, may play a pivotal role in the expression of stress-induced motor suppression, whereas enkephalins may act to attenuate this response.

Original languageEnglish
Pages (from-to)133-145
Number of pages13
JournalBehavioural Brain Research
Volume67
Issue number2
DOIs
Publication statusPublished - 01-01-1995
Externally publishedYes

Fingerprint

Analgesia
Opioid Analgesics
Opioid Receptors
Brain
Catalepsy
Dynorphins
Opioid Peptides
Narcotic Antagonists
Enkephalins
Pharmacology
Pain
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

@article{28033121ef244c98b496895860d48eed,
title = "Stress-induced behavioral responses and multiple opioid systems in the brain",
abstract = "Various stressor produce a wide range of behavioral responses such as analgesia, catalepsy and motor suppression, which are sensitive to opioid receptor antagonists. These behavioral responses in stress are accompanied by changes in the contents of opioid peptides, the mRNAs encoding their precursors and opioid receptor binding in the brain. In the present article, experimental data concerning stress-induced analgesia and motor suppression is reviewed and discussed in relation to a possible involvement of different opioid systems in the various observed behavioral responses in stress. Pharmacological studies with subtype-selective antagonists have demonstrated that not only μ- but also δ- and/or κ-opioid receptors are involved in opioid-mediated stress-induced analgesia. There are two types of stress-induced analgesia referred to as opioid-mediated and non-opioid mediated forms. It has been proposed that the intensity and temporal pattern of stressor may be a critical factor determining the nature of stress-induced analgesia. Accumulated evidence demonstrate that these two foms of pain inhibitory systems interact each other according to a collateral inhibition model. Recent studies show that parallel activation of multiple opioid receptors mediates non-opioid forms of stress-induced analgesia. Dynorphins, by acting at κ-opioid receptors, may play a pivotal role in the expression of stress-induced motor suppression, whereas enkephalins may act to attenuate this response.",
author = "Kiyofumi Yamada and Toshitaka Nabeshima",
year = "1995",
month = "1",
day = "1",
doi = "10.1016/0166-4328(94)00150-E",
language = "English",
volume = "67",
pages = "133--145",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "2",

}

Stress-induced behavioral responses and multiple opioid systems in the brain. / Yamada, Kiyofumi; Nabeshima, Toshitaka.

In: Behavioural Brain Research, Vol. 67, No. 2, 01.01.1995, p. 133-145.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Stress-induced behavioral responses and multiple opioid systems in the brain

AU - Yamada, Kiyofumi

AU - Nabeshima, Toshitaka

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Various stressor produce a wide range of behavioral responses such as analgesia, catalepsy and motor suppression, which are sensitive to opioid receptor antagonists. These behavioral responses in stress are accompanied by changes in the contents of opioid peptides, the mRNAs encoding their precursors and opioid receptor binding in the brain. In the present article, experimental data concerning stress-induced analgesia and motor suppression is reviewed and discussed in relation to a possible involvement of different opioid systems in the various observed behavioral responses in stress. Pharmacological studies with subtype-selective antagonists have demonstrated that not only μ- but also δ- and/or κ-opioid receptors are involved in opioid-mediated stress-induced analgesia. There are two types of stress-induced analgesia referred to as opioid-mediated and non-opioid mediated forms. It has been proposed that the intensity and temporal pattern of stressor may be a critical factor determining the nature of stress-induced analgesia. Accumulated evidence demonstrate that these two foms of pain inhibitory systems interact each other according to a collateral inhibition model. Recent studies show that parallel activation of multiple opioid receptors mediates non-opioid forms of stress-induced analgesia. Dynorphins, by acting at κ-opioid receptors, may play a pivotal role in the expression of stress-induced motor suppression, whereas enkephalins may act to attenuate this response.

AB - Various stressor produce a wide range of behavioral responses such as analgesia, catalepsy and motor suppression, which are sensitive to opioid receptor antagonists. These behavioral responses in stress are accompanied by changes in the contents of opioid peptides, the mRNAs encoding their precursors and opioid receptor binding in the brain. In the present article, experimental data concerning stress-induced analgesia and motor suppression is reviewed and discussed in relation to a possible involvement of different opioid systems in the various observed behavioral responses in stress. Pharmacological studies with subtype-selective antagonists have demonstrated that not only μ- but also δ- and/or κ-opioid receptors are involved in opioid-mediated stress-induced analgesia. There are two types of stress-induced analgesia referred to as opioid-mediated and non-opioid mediated forms. It has been proposed that the intensity and temporal pattern of stressor may be a critical factor determining the nature of stress-induced analgesia. Accumulated evidence demonstrate that these two foms of pain inhibitory systems interact each other according to a collateral inhibition model. Recent studies show that parallel activation of multiple opioid receptors mediates non-opioid forms of stress-induced analgesia. Dynorphins, by acting at κ-opioid receptors, may play a pivotal role in the expression of stress-induced motor suppression, whereas enkephalins may act to attenuate this response.

UR - http://www.scopus.com/inward/record.url?scp=0028960799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028960799&partnerID=8YFLogxK

U2 - 10.1016/0166-4328(94)00150-E

DO - 10.1016/0166-4328(94)00150-E

M3 - Review article

VL - 67

SP - 133

EP - 145

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 2

ER -