Stress-induced changes in brain Met-enkephalin, Leu-enkephalin and dynorphin concentrations

Toshitaka Nabeshima, Akira Katoh, Masako Wada, Tsutomu Kameyama

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Methionine-enkephalin (Met-enkephalin), leucine-enkephalin (Leu-enkephalin) and dynorphin A (1-17) (dynorphin A) concentrations in discrete brain areas were determined in the mice showing behavioral changes induced by stress using radioimmunoassay (RIA). In the present experiment, we used environment-induced conditioned suppression of motility and forced swimming-induced immobility. In the environment-induced conditioned suppression of motility, Met-enkephalin concentration in the striatum and hypothalamus significantly decreased. Leu-enkephalin concentration in the hypothalamus also decreased. Dynorphin A concentraion in the striatum decreased, but significantly increased in the hypothalamus and pituitary. In the forced swimming-induced immobility, Met-enkephalin concentration in the striatum significantly decreased. Leu-enkephalin concentration in the hypothalamus and pituitary significantly decreased. Dynorphin A concentration in the pituitary decreased, but significantly increased in the hypothalamus. Our results indicated that the concentrations of Met-enkephalin, Leu-enkephalin and dynorphin A in the discrete brain areas changed in two different stressful situations. These findings suggested that these peptides might modulate the behavioral changes induced by stressors.

Original languageEnglish
Pages (from-to)211-217
Number of pages7
JournalLife Sciences
Volume51
Issue number3
DOIs
Publication statusPublished - 01-01-1992
Externally publishedYes

Fingerprint

Leucine Enkephalin
Dynorphins
Methionine Enkephalin
Hypothalamus
Brain
Radioimmunoassay
Peptides
Experiments

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Nabeshima, Toshitaka ; Katoh, Akira ; Wada, Masako ; Kameyama, Tsutomu. / Stress-induced changes in brain Met-enkephalin, Leu-enkephalin and dynorphin concentrations. In: Life Sciences. 1992 ; Vol. 51, No. 3. pp. 211-217.
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Stress-induced changes in brain Met-enkephalin, Leu-enkephalin and dynorphin concentrations. / Nabeshima, Toshitaka; Katoh, Akira; Wada, Masako; Kameyama, Tsutomu.

In: Life Sciences, Vol. 51, No. 3, 01.01.1992, p. 211-217.

Research output: Contribution to journalArticle

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