Structural and functional evolution of three cardiac natriuretic peptides

Koji Inoue, Takashi Sakamoto, Shinya Yuge, Hozi Iwatani, Sayaka Yamagami, Makiko Tsutsumi, Hiroshi Hori, Maria Carmela Cerra, Bruno Tota, Norio Suzuki, Nobuaki Okamoto, Yoshio Takei

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Natriuretic peptides (NPs) are a group of hormones playing important roles in cardiovascular and osmoregulatory systems in vertebrates. Among the NP subtypes, atrial NP (ANP), B-type NP (BNP), and ventricular NP (VNP) are circulating hormones expressed exclusively in the heart (cardiac NPs). The constitution of cardiac NPs is variable among species of vertebrates. In order to understand the evolutionary and functional significance of such variation, we performed a systematic survey of cardiac NP cDNAs in nine taxonomically diverse teleosts inhabiting environments of varying salinity. The discovery of the coexistence of the ANP, BNP, and VNP genes in the eel and rainbow trout suggested that the ancestral teleost had all three cardiac NPs. As the VNP cDNA was undetectable in ayu and six species of Neoteleostei, it is possible that VNP was lost before the divergence of Osmeroidei. The ANP gene was also undetectable in the medaka. Thus, only the BNP gene is universal in species examined in the present study. Synthetic medaka BNP preferentially activated two medaka GC-A-type receptors, suggesting that the three cardiac NPs share the same receptor. However, the regulation of BNP expression may be the most strict because ATTTA repeats in the 3′-untranslated region and the dibasic motif in the ring are conserved among teleosts and tetrapods. Linkage analyses in the rainbow trout located ANP, BNP, and VNP genes on the same chromosome, which suggested the generation of the VNP gene by tandem duplication as observed with ANP and BNP genes. If the duplication occurred before the divergence of tetrapods and teleosts, VNP may exist in the tetrapod lineage.

Original languageEnglish
Pages (from-to)2428-2434
Number of pages7
JournalMolecular Biology and Evolution
Volume22
Issue number12
DOIs
Publication statusPublished - 01-12-2005

Fingerprint

natriuretic peptides
Natriuretic Peptides
peptide
Oryzias
teleost
tetrapod
gene
Genes
Oncorhynchus mykiss
genes
Vertebrates
Osmeriformes
Complementary DNA
rainbow
hormone
vertebrates
vertebrate
hormones
Eels
divergence

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Cite this

Inoue, K., Sakamoto, T., Yuge, S., Iwatani, H., Yamagami, S., Tsutsumi, M., ... Takei, Y. (2005). Structural and functional evolution of three cardiac natriuretic peptides. Molecular Biology and Evolution, 22(12), 2428-2434. https://doi.org/10.1093/molbev/msi243
Inoue, Koji ; Sakamoto, Takashi ; Yuge, Shinya ; Iwatani, Hozi ; Yamagami, Sayaka ; Tsutsumi, Makiko ; Hori, Hiroshi ; Cerra, Maria Carmela ; Tota, Bruno ; Suzuki, Norio ; Okamoto, Nobuaki ; Takei, Yoshio. / Structural and functional evolution of three cardiac natriuretic peptides. In: Molecular Biology and Evolution. 2005 ; Vol. 22, No. 12. pp. 2428-2434.
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Inoue, K, Sakamoto, T, Yuge, S, Iwatani, H, Yamagami, S, Tsutsumi, M, Hori, H, Cerra, MC, Tota, B, Suzuki, N, Okamoto, N & Takei, Y 2005, 'Structural and functional evolution of three cardiac natriuretic peptides', Molecular Biology and Evolution, vol. 22, no. 12, pp. 2428-2434. https://doi.org/10.1093/molbev/msi243

Structural and functional evolution of three cardiac natriuretic peptides. / Inoue, Koji; Sakamoto, Takashi; Yuge, Shinya; Iwatani, Hozi; Yamagami, Sayaka; Tsutsumi, Makiko; Hori, Hiroshi; Cerra, Maria Carmela; Tota, Bruno; Suzuki, Norio; Okamoto, Nobuaki; Takei, Yoshio.

In: Molecular Biology and Evolution, Vol. 22, No. 12, 01.12.2005, p. 2428-2434.

Research output: Contribution to journalArticle

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T1 - Structural and functional evolution of three cardiac natriuretic peptides

AU - Inoue, Koji

AU - Sakamoto, Takashi

AU - Yuge, Shinya

AU - Iwatani, Hozi

AU - Yamagami, Sayaka

AU - Tsutsumi, Makiko

AU - Hori, Hiroshi

AU - Cerra, Maria Carmela

AU - Tota, Bruno

AU - Suzuki, Norio

AU - Okamoto, Nobuaki

AU - Takei, Yoshio

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