Structure and function of snake venom proteins affecting platelet plug formation

Taei Matsui, Jiharu Hamako, Koiti Titani

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Many snake venom proteins have been isolated that affect platelet plug formation by interacting either with platelet integrins, membrane glycoprotein Ib (GPIb), or plasma von Willebrand factor (VWF). Among them, disintegrins purified from various snake venoms are strong inhibitors of platelet aggregation. Botrocetin and bitiscetin derived from Bothrops jararaca and Bitis arietans venom, respectively, induce VWF-dependent platelet agglutination in vitro. Several GPIb-binding proteins have also been isolated from snake venoms. In this review, we focus on the structure and function of those snake venom proteins that influence platelet plug formation. These proteins are potentially useful as reagents for the sub-diagnosis of platelet disorder or von Willebrand disease, as well as for clinical and basic research of thrombosis and hemostasis.

Original languageEnglish
Pages (from-to)10-23
Number of pages14
JournalToxins
Volume2
Issue number1
DOIs
Publication statusPublished - 01-2010

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

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