Structure of Acrosome Reaction-Inducing Steroidal Saponins from the Egg Jelly of the Starfish, Asterias amurensis

Yoshinori Fujimoto, Taketoshi Yamada, Nobuo Ikekawa, Taei Matsui, Ichiro Nishiyama, Motonori Hoshi

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Three steroidal saponins (designated as Co-ARIS I, II, III) which are essential for inducing the acrosome reaction, were isolated from the egg jelly of the starfish, Asterias amurensis, and their structures were elucidated by chemical and spectral means. The structure of Co-ARIS II was determined to be 6α-O-{O-β-D-fucopyranosyl-(1→2)-O-β-D-fucopyranosyl-(l→ 4)-[O-β-d-quinovopyranosyl-(1→ 2)]-O-β-D-quinovopyranosyl-(l→3)-6-deoxy-β-D-xylo-hexos-4-ulopyranos-l-yl}-3β-hydroxysulfonyloxy-5α-cholesta-9(l 1), 17(20),24-trien-23-one (2), whereas Co-ARIS I (1) and Co-ARIS III (3) were identical with ovarian asterosaponin-1 (OA-1) and OA-4 previously isolated from the same species of starfish.

Original languageEnglish
Pages (from-to)1829-1832
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume35
Issue number5
DOIs
Publication statusPublished - 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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