Structure of constituents isolated from the bark of Cassipourea malosana and their cytotoxicity against a human ovarian cell line

Yumi Nishiyama; Yuki Noda; Noriyoshi Nakatani; Nobukazu Shitan; Tamotsu Sudo; Atsushi Kato; Patrick B. Chalo Mutiso

doi:10.1007/s11418-018-1254-2

Structure of constituents isolated from the bark of Cassipourea malosana and their cytotoxicity against a human ovarian cell line

Yumi Nishiyama
, Yuki Noda
, Noriyoshi Nakatani
, Nobukazu Shitan
, Tamotsu Sudo
, Atsushi Kato
, Patrick B. Chalo Mutiso

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Three aromatic compounds, 2α,3α-epoxyflavan-5,7,4′-triol-(4β → 8)-afzelechin (1), 2β,3β-epoxyflavan-5,7,4′-triol-(4α → 8)-epiafzelechin (2), and methyl 4-ethoxy-2-hydroxy-6-propylbenzoate (3), as well as eight known compounds (4–11) were isolated from the bark of Cassipourea malosana (Rhizophoraceae). Their structures were determined on the basis of an analysis of spectroscopic data. The in vitro cytotoxic activities of these compounds against human ovarian cancer cell line TOV21G were evaluated. Most compounds showed little activity; however, the methyl derivatives of flavan dimers (1a and 2a) showed higher activity (IC ₅₀ value of 30.3 and 75.4 μM) than parent compounds 1 and 2.

Original language	English
Pages (from-to)	289-296
Number of pages	8
Journal	Journal of Natural Medicines
Volume	73
Issue number	1
DOIs	https://doi.org/10.1007/s11418-018-1254-2
Publication status	Published - 25-01-2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1007/s11418-018-1254-2

Cite this

@article{d9386d43fa244ff68782095ee99c61ba,

title = "Structure of constituents isolated from the bark of Cassipourea malosana and their cytotoxicity against a human ovarian cell line",

abstract = " Three aromatic compounds, 2α,3α-epoxyflavan-5,7,4′-triol-(4β → 8)-afzelechin (1), 2β,3β-epoxyflavan-5,7,4′-triol-(4α → 8)-epiafzelechin (2), and methyl 4-ethoxy-2-hydroxy-6-propylbenzoate (3), as well as eight known compounds (4–11) were isolated from the bark of Cassipourea malosana (Rhizophoraceae). Their structures were determined on the basis of an analysis of spectroscopic data. The in vitro cytotoxic activities of these compounds against human ovarian cancer cell line TOV21G were evaluated. Most compounds showed little activity; however, the methyl derivatives of flavan dimers (1a and 2a) showed higher activity (IC 50 value of 30.3 and 75.4 μM) than parent compounds 1 and 2.",

keywords = "Cassipourea malosana, Flavan dimer, Ovarian cancer cell, Rhizophoraceae",

author = "Yumi Nishiyama and Yuki Noda and Noriyoshi Nakatani and Nobukazu Shitan and Tamotsu Sudo and Atsushi Kato and \{Chalo Mutiso\}, \{Patrick B.\}",

note = "Publisher Copyright: {\textcopyright} 2018, The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature.",

year = "2019",

month = jan,

day = "25",

doi = "10.1007/s11418-018-1254-2",

language = "English",

volume = "73",

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T1 - Structure of constituents isolated from the bark of Cassipourea malosana and their cytotoxicity against a human ovarian cell line

AU - Nishiyama, Yumi

AU - Noda, Yuki

AU - Nakatani, Noriyoshi

AU - Shitan, Nobukazu

AU - Sudo, Tamotsu

AU - Kato, Atsushi

AU - Chalo Mutiso, Patrick B.

PY - 2019/1/25

Y1 - 2019/1/25

N2 - Three aromatic compounds, 2α,3α-epoxyflavan-5,7,4′-triol-(4β → 8)-afzelechin (1), 2β,3β-epoxyflavan-5,7,4′-triol-(4α → 8)-epiafzelechin (2), and methyl 4-ethoxy-2-hydroxy-6-propylbenzoate (3), as well as eight known compounds (4–11) were isolated from the bark of Cassipourea malosana (Rhizophoraceae). Their structures were determined on the basis of an analysis of spectroscopic data. The in vitro cytotoxic activities of these compounds against human ovarian cancer cell line TOV21G were evaluated. Most compounds showed little activity; however, the methyl derivatives of flavan dimers (1a and 2a) showed higher activity (IC 50 value of 30.3 and 75.4 μM) than parent compounds 1 and 2.

AB - Three aromatic compounds, 2α,3α-epoxyflavan-5,7,4′-triol-(4β → 8)-afzelechin (1), 2β,3β-epoxyflavan-5,7,4′-triol-(4α → 8)-epiafzelechin (2), and methyl 4-ethoxy-2-hydroxy-6-propylbenzoate (3), as well as eight known compounds (4–11) were isolated from the bark of Cassipourea malosana (Rhizophoraceae). Their structures were determined on the basis of an analysis of spectroscopic data. The in vitro cytotoxic activities of these compounds against human ovarian cancer cell line TOV21G were evaluated. Most compounds showed little activity; however, the methyl derivatives of flavan dimers (1a and 2a) showed higher activity (IC 50 value of 30.3 and 75.4 μM) than parent compounds 1 and 2.

KW - Cassipourea malosana

KW - Flavan dimer

KW - Ovarian cancer cell

KW - Rhizophoraceae

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UR - https://www.scopus.com/pages/publications/85055681244#tab=citedBy

U2 - 10.1007/s11418-018-1254-2

DO - 10.1007/s11418-018-1254-2

M3 - Article

C2 - 30353358

AN - SCOPUS:85055681244

SN - 1340-3443

VL - 73

SP - 289

EP - 296

JO - Journal of Natural Medicines

JF - Journal of Natural Medicines

IS - 1

ER -

Structure of constituents isolated from the bark of Cassipourea malosana and their cytotoxicity against a human ovarian cell line

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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