Study on the molecular pathogenesis of human papillomavirus (HPV)-related squamous cell carcinoma of the tongue-base region and tonsil

Hisayuki Kato, Takehiro Yui, Tatsuyoshi Okada, Kazuo Sakurai, Naoki Yamamoto

Research output: Contribution to journalArticle

Abstract

We investigated the prevalence of high-risk human papillomavirus (HR-HPV) in squamous cell carcinoma of the tonsil and tongue-base region, and evaluated its clinical features and prognostic implications according to HPV status and p16 and p53 expression. HR-HPV was positive in 16 (53%) of 30 samples. Of these positive cases, 15 (94%) carried HPV 16 sequences and only 1 (6%) carried a HPV58 sequence. Among the HPV-positive patients, the frequency of heavy smokers and drinkers was significantly lower than among the HPV-negative patients. Among the 30 patients, p16 was overexpressed in 16 (53%), and this overexpression was strongly associated with the presence of HR-HPV (P < 0.0001). In contrast, HPV-negative patients were more likely to have p53 overexpression (75%). On univariate analysis, both HPV-positive status (86% vs. 48%; P = 0.029) and p16 overexpression (100% vs. 31%; P < 0.001) significantly improved the overall survival (OS), respectively. On the other hand, p53 overexpression was significantly associated with inferior OS (42% vs. 83%; P = 0.004). These results indicate that it will be necessary to use these HPV-related biomarkers for decisions on staging and therapeutic strategy.

Original languageEnglish
Pages (from-to)339-343
Number of pages5
JournalToukeibu Gan
Volume36
Issue number3
DOIs
Publication statusPublished - 01-01-2010

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Palatine Tonsil
Tongue
Squamous Cell Carcinoma
Survival
Human papillomavirus 16
Biomarkers

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Oncology

Cite this

Kato, Hisayuki ; Yui, Takehiro ; Okada, Tatsuyoshi ; Sakurai, Kazuo ; Yamamoto, Naoki. / Study on the molecular pathogenesis of human papillomavirus (HPV)-related squamous cell carcinoma of the tongue-base region and tonsil. In: Toukeibu Gan. 2010 ; Vol. 36, No. 3. pp. 339-343.
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abstract = "We investigated the prevalence of high-risk human papillomavirus (HR-HPV) in squamous cell carcinoma of the tonsil and tongue-base region, and evaluated its clinical features and prognostic implications according to HPV status and p16 and p53 expression. HR-HPV was positive in 16 (53{\%}) of 30 samples. Of these positive cases, 15 (94{\%}) carried HPV 16 sequences and only 1 (6{\%}) carried a HPV58 sequence. Among the HPV-positive patients, the frequency of heavy smokers and drinkers was significantly lower than among the HPV-negative patients. Among the 30 patients, p16 was overexpressed in 16 (53{\%}), and this overexpression was strongly associated with the presence of HR-HPV (P < 0.0001). In contrast, HPV-negative patients were more likely to have p53 overexpression (75{\%}). On univariate analysis, both HPV-positive status (86{\%} vs. 48{\%}; P = 0.029) and p16 overexpression (100{\%} vs. 31{\%}; P < 0.001) significantly improved the overall survival (OS), respectively. On the other hand, p53 overexpression was significantly associated with inferior OS (42{\%} vs. 83{\%}; P = 0.004). These results indicate that it will be necessary to use these HPV-related biomarkers for decisions on staging and therapeutic strategy.",
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Study on the molecular pathogenesis of human papillomavirus (HPV)-related squamous cell carcinoma of the tongue-base region and tonsil. / Kato, Hisayuki; Yui, Takehiro; Okada, Tatsuyoshi; Sakurai, Kazuo; Yamamoto, Naoki.

In: Toukeibu Gan, Vol. 36, No. 3, 01.01.2010, p. 339-343.

Research output: Contribution to journalArticle

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