Subarachnoid hemorrhage caused by an undifferentiated sarcoma of the sellar region

Tsukasa Ganaha, Joji Inamasu, Motoki Oheda, Mitsuhiro Hasegawa, Yuichi Hirose, Masato Abe

Research output: Contribution to journalArticle

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Abstract

Background: It is rare for patients with pituitary apoplexy to exhibit concomitant subarachnoid hemorrhage (SAH). Only a handful of patients with pituitary apoplexy have developed such hemorrhagic complications, and histopathological examination revealed pituitary adenoma as the cause of SAH. Case Report: A previously healthy 35-year-old woman was brought to our institution after complaining of severe headache and left monocular blindness. Brain computed tomography showed a diffuse SAH with a central low density. Subsequently, the brain magnetic resonance imaging revealed an intrasellar mass with heterogeneous contrast enhancement. The patient was presumptively diagnosed with SAH secondary to hemorrhagic pituitary adenoma and underwent transcranial surgery to remove both the tumor and subarachnoid clot. A histological evaluation of the surgical specimen revealed malignant cells with strong predilection for vascular invasion. Following immunohistochemical evaluation, the tumor was negative for the majority of tumor markers and was positive only for vimentin and p53; thus, a diagnosis of undifferentiated sarcoma was established. Conclusions: This case was informative in the respect that tumors other than pituitary adenoma should be included in the differential diagnosis of patients with pituitary apoplexy.

Original languageEnglish
Pages (from-to)S459-S462
JournalSurgical Neurology International
Volume7
Issue number17
DOIs
Publication statusPublished - 01-12-2016

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Pituitary Apoplexy
Subarachnoid Hemorrhage
Sarcoma
Pituitary Neoplasms
Neoplasms
Brain
Vimentin
Blindness
Tumor Biomarkers
Blood Vessels
Headache
Differential Diagnosis
Tomography
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Ganaha, Tsukasa ; Inamasu, Joji ; Oheda, Motoki ; Hasegawa, Mitsuhiro ; Hirose, Yuichi ; Abe, Masato. / Subarachnoid hemorrhage caused by an undifferentiated sarcoma of the sellar region. In: Surgical Neurology International. 2016 ; Vol. 7, No. 17. pp. S459-S462.
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Subarachnoid hemorrhage caused by an undifferentiated sarcoma of the sellar region. / Ganaha, Tsukasa; Inamasu, Joji; Oheda, Motoki; Hasegawa, Mitsuhiro; Hirose, Yuichi; Abe, Masato.

In: Surgical Neurology International, Vol. 7, No. 17, 01.12.2016, p. S459-S462.

Research output: Contribution to journalArticle

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