Subclinical idiopathic pulmonary fibrosis is also a risk factor of postoperative acute respiratory distress syndrome following thoracic surgery

Masayuki Chida, Shuichi Ono, Yasushi Hoshikawa, Takashi Kondo

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objective: Postoperative acute interstitial pneumonia is a subset of post-surgical acute respiratory distress syndrome (ARDS) and is responsible for one third of in-hospital deaths following lung resection in patients with primary lung cancer. We evaluated the usefulness of computed tomography (CT) for detection of interstitial pneumonia (IP) as a risk factor of postoperative ARDS. Methods: Preoperative chest CT of patients who underwent thoracotomy for primary lung cancer was reviewed retrospectively and IP findings in the chest CT were detected. Results: A total of 1148 patients with primary lung cancer underwent thoracotomy. Fifteen patients (1.3%) developed postoperative ARDS. Eleven of these 15 patients died of ARDS. Three of 41 patients who received induction therapy developed postoperative ARDS. Induction therapy was a risk factor of postoperative ARDS (p < 0.01). Eleven out of the 15 patients who developed postoperative ARDS had IP findings (10: localized, 1: diffuse) in their chest CT. Two of three patients who had postoperative ARDS after induction therapy also had IP findings. Chest CTs of 834 patients were retrospectively analyzed; 91 patients (10.9%) had IP-findings (diffuse 1.8%, localized 9.1%). Postoperative ARDS occurred in 8.8% of IP-positive patients, and in 0.4% of IP-negative patients (p < 0.001). Conclusion: Detection of IP by chest CT is useful for the selection of high-risk patients who may have postoperative ARDS following thoracotomy.

Original languageEnglish
Pages (from-to)878-881
Number of pages4
JournalEuropean Journal of Cardio-thoracic Surgery
Volume34
Issue number4
DOIs
Publication statusPublished - 01-10-2008

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Idiopathic Pulmonary Fibrosis
Adult Respiratory Distress Syndrome
Thoracic Surgery
Interstitial Lung Diseases
Thorax
Tomography
Thoracotomy
Lung Neoplasms

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

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title = "Subclinical idiopathic pulmonary fibrosis is also a risk factor of postoperative acute respiratory distress syndrome following thoracic surgery",
abstract = "Objective: Postoperative acute interstitial pneumonia is a subset of post-surgical acute respiratory distress syndrome (ARDS) and is responsible for one third of in-hospital deaths following lung resection in patients with primary lung cancer. We evaluated the usefulness of computed tomography (CT) for detection of interstitial pneumonia (IP) as a risk factor of postoperative ARDS. Methods: Preoperative chest CT of patients who underwent thoracotomy for primary lung cancer was reviewed retrospectively and IP findings in the chest CT were detected. Results: A total of 1148 patients with primary lung cancer underwent thoracotomy. Fifteen patients (1.3{\%}) developed postoperative ARDS. Eleven of these 15 patients died of ARDS. Three of 41 patients who received induction therapy developed postoperative ARDS. Induction therapy was a risk factor of postoperative ARDS (p < 0.01). Eleven out of the 15 patients who developed postoperative ARDS had IP findings (10: localized, 1: diffuse) in their chest CT. Two of three patients who had postoperative ARDS after induction therapy also had IP findings. Chest CTs of 834 patients were retrospectively analyzed; 91 patients (10.9{\%}) had IP-findings (diffuse 1.8{\%}, localized 9.1{\%}). Postoperative ARDS occurred in 8.8{\%} of IP-positive patients, and in 0.4{\%} of IP-negative patients (p < 0.001). Conclusion: Detection of IP by chest CT is useful for the selection of high-risk patients who may have postoperative ARDS following thoracotomy.",
author = "Masayuki Chida and Shuichi Ono and Yasushi Hoshikawa and Takashi Kondo",
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Subclinical idiopathic pulmonary fibrosis is also a risk factor of postoperative acute respiratory distress syndrome following thoracic surgery. / Chida, Masayuki; Ono, Shuichi; Hoshikawa, Yasushi; Kondo, Takashi.

In: European Journal of Cardio-thoracic Surgery, Vol. 34, No. 4, 01.10.2008, p. 878-881.

Research output: Contribution to journalArticle

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AU - Ono, Shuichi

AU - Hoshikawa, Yasushi

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