Subcutaneous tissue distribution of vancomycin from a fibrin glue/Dacron graft carrier

Katsuhiro Fujimoto, Keiko Yamamura, Takashi Osada, Tetsuo Hayashi, Toshitaka Nabeshima, Masahiro Matsushita, Naomichi Nishikimi, Tsunehisa Sakurai, Yuji Nimura

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Abstract

We investigated the tissue distribution of vancomycin (VCM) incorporated in fibrin glue (FG) in a rat model. One VCM-loaded FG Dacron graft (VCM-FG, VCM 0.6 mg/graft) was implanted in the subcutaneous tissue of the anterior abdominal wall of each rat. VCM was injected intravenously at an equal dose (0.6 mg/rat) after implantation of one control graft (without VCM-FG). After the implantation and the iv injection of an equal dose of VCM (0.6 mg/rat), the tissue distribution of VCM for up to 24 h was determined through analysis of the implanted VCM-FG grafts, which releasd VCM over a 24 h period. The area under the VCM concentration-time curve (AUC) of the tissue was 89.58 μg · h/g after the implantation of the VCM-FG graft, and 7.40 μg · h/g after the iv injection of VCM, respectively. The targeting index of the tissue, defined as the ratio of AUC after the implantation of the VCM-FG graft to that after VCM iv injection, was 12.11. None of the six VCM-FG Dacron grafts after implantation became infected following inoculation with S. aureus ATCC 25923 (0.1 mL 108 CFU/mL). These results suggest that this VCM-FG Dacron graft delivery may be useful in preventing local infection by enhancing the delivery of VCM to the local areas of the implanted site in rats.

Original languageEnglish
Pages (from-to)564-567
Number of pages4
JournalJournal of Biomedical Materials Research
Volume36
Issue number4
DOIs
Publication statusPublished - 15-09-1997

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

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    Fujimoto, K., Yamamura, K., Osada, T., Hayashi, T., Nabeshima, T., Matsushita, M., Nishikimi, N., Sakurai, T., & Nimura, Y. (1997). Subcutaneous tissue distribution of vancomycin from a fibrin glue/Dacron graft carrier. Journal of Biomedical Materials Research, 36(4), 564-567. https://doi.org/10.1002/(SICI)1097-4636(19970915)36:4<564::AID-JBM16>3.0.CO;2-A