Subcutaneous tissue release of amikacin from a fibrin glue/polyurethane graft

Kazuo Nishimoto, Keiko Yamamura, Fumiaki Fukase, Masayoshi Kobayashi, Naomichi Nishikimi, Kimihiro Komori

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We investigated whether fibrin glue (FG) might be useful as a carrier of amikacin (AMK) for prevention of local graft infection. After AMK (4.0mg)-treated FG (AMK-FG) polyurethane grafts were implanted subcutaneously in the anterior abdominal region of Sprague-Dawley rats, AMK concentrations in tissues surrounding the implantation sites were compared over time with concentrations at the same sites in rats given an intravenous injection of AMK (4.0mg). In the injection group, AMK concentrations in serum were detectable only for 4h, whereas AMK released from AMK-FG grafts remained detectable over 24h. Until 4h after implantation, AMK concentrations in tissues near implantation sites were significantly higher in the AMK-FG graft group than in the injection group; peak local concentrations during that time were 210 times higher for the AMK-FG graft group than for the injection group. Areas under the tissue concentration-time curve (AUC) for AMK were 171 μg·h/g and 1. 35 μg·h/g in the AMK-FG graft and injection groups, respectively. FG therefore was considered to control release of AMK and to maintain a high AMK concentration in tissues surrounding the implantation site. Thus, AMK-FG polyurethane graft delivery may be useful in preventing local infection by local delivery of AMK.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalJournal of Infection and Chemotherapy
Volume10
Issue number2
DOIs
Publication statusPublished - 04-2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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