Subtle myocardial damage associated with diagnostic coronary angiography alone

Hisashi Umeda, Tomoyuki Ota, Mitsunori Iwase, Hideo Izawa, Shinjiro Miyata, Shigeo Sugino, Kazutaka Hayashi, Naoki Misumida, Yasushi Takeichi, Ryoji Ishiki, Haruo Inagaki, Toyoaki Murohara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aims: To evaluate the frequency, predictors and prognostic significance of elevation in cardiac troponin I (cTnI) after coronary angiography (CAG). Methods and results: A series of 296 consecutive patients with normal pre-procedural cTnI levels and undergoing elective CAG at our centre were prospectively analysed. Positive cTnI elevation was defined as >0.06 ng/ml. Positive cTnI elevation was observed in 44 patients (14.8%), but CK-MB was elevated in only four patients (1.3%) after the procedure. The risk of cTnI elevation was independently associated with left ventricular hypertrophy (odds ratio [OR] 5.52; 95% confidence interval [CI], 2.54 to 12.02; P<0.001), inexperienced operator (OR 10.83; 95% CI, 2.47 to 47.43; P=0.002) and the amount of contrast agent (OR 1.12; 95% CI, 1.03 to 1.23; P=0.009 for each 10 ml increase), whereas it was not associated with the severity of coronary artery disease. At one year, however, postprocedural elevation of cTnI was not associated with an increased risk of death (2.3% vs. 0.8%, P=0.384) or myocardial infarction (2.3% vs. 2.0%, P=0.623). Conclusions: A minor elevation of cTnI is observed commonly after CAG, which might be associated with left ventricular hypertrophy, operator's experience and the amount of contrast used; however, it does not influence 1-year events rates.

Original languageEnglish
Pages (from-to)388-393
Number of pages6
JournalEuroIntervention
Volume6
Issue number3
DOIs
Publication statusPublished - 01-08-2010

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Troponin I
Coronary Angiography
Odds Ratio
Left Ventricular Hypertrophy
Confidence Intervals
Contrast Media
Coronary Artery Disease
Myocardial Infarction

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Umeda, H., Ota, T., Iwase, M., Izawa, H., Miyata, S., Sugino, S., ... Murohara, T. (2010). Subtle myocardial damage associated with diagnostic coronary angiography alone. EuroIntervention, 6(3), 388-393. https://doi.org/10.4244/EIJV6I3A64
Umeda, Hisashi ; Ota, Tomoyuki ; Iwase, Mitsunori ; Izawa, Hideo ; Miyata, Shinjiro ; Sugino, Shigeo ; Hayashi, Kazutaka ; Misumida, Naoki ; Takeichi, Yasushi ; Ishiki, Ryoji ; Inagaki, Haruo ; Murohara, Toyoaki. / Subtle myocardial damage associated with diagnostic coronary angiography alone. In: EuroIntervention. 2010 ; Vol. 6, No. 3. pp. 388-393.
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abstract = "Aims: To evaluate the frequency, predictors and prognostic significance of elevation in cardiac troponin I (cTnI) after coronary angiography (CAG). Methods and results: A series of 296 consecutive patients with normal pre-procedural cTnI levels and undergoing elective CAG at our centre were prospectively analysed. Positive cTnI elevation was defined as >0.06 ng/ml. Positive cTnI elevation was observed in 44 patients (14.8{\%}), but CK-MB was elevated in only four patients (1.3{\%}) after the procedure. The risk of cTnI elevation was independently associated with left ventricular hypertrophy (odds ratio [OR] 5.52; 95{\%} confidence interval [CI], 2.54 to 12.02; P<0.001), inexperienced operator (OR 10.83; 95{\%} CI, 2.47 to 47.43; P=0.002) and the amount of contrast agent (OR 1.12; 95{\%} CI, 1.03 to 1.23; P=0.009 for each 10 ml increase), whereas it was not associated with the severity of coronary artery disease. At one year, however, postprocedural elevation of cTnI was not associated with an increased risk of death (2.3{\%} vs. 0.8{\%}, P=0.384) or myocardial infarction (2.3{\%} vs. 2.0{\%}, P=0.623). Conclusions: A minor elevation of cTnI is observed commonly after CAG, which might be associated with left ventricular hypertrophy, operator's experience and the amount of contrast used; however, it does not influence 1-year events rates.",
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Umeda, H, Ota, T, Iwase, M, Izawa, H, Miyata, S, Sugino, S, Hayashi, K, Misumida, N, Takeichi, Y, Ishiki, R, Inagaki, H & Murohara, T 2010, 'Subtle myocardial damage associated with diagnostic coronary angiography alone', EuroIntervention, vol. 6, no. 3, pp. 388-393. https://doi.org/10.4244/EIJV6I3A64

Subtle myocardial damage associated with diagnostic coronary angiography alone. / Umeda, Hisashi; Ota, Tomoyuki; Iwase, Mitsunori; Izawa, Hideo; Miyata, Shinjiro; Sugino, Shigeo; Hayashi, Kazutaka; Misumida, Naoki; Takeichi, Yasushi; Ishiki, Ryoji; Inagaki, Haruo; Murohara, Toyoaki.

In: EuroIntervention, Vol. 6, No. 3, 01.08.2010, p. 388-393.

Research output: Contribution to journalArticle

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T1 - Subtle myocardial damage associated with diagnostic coronary angiography alone

AU - Umeda, Hisashi

AU - Ota, Tomoyuki

AU - Iwase, Mitsunori

AU - Izawa, Hideo

AU - Miyata, Shinjiro

AU - Sugino, Shigeo

AU - Hayashi, Kazutaka

AU - Misumida, Naoki

AU - Takeichi, Yasushi

AU - Ishiki, Ryoji

AU - Inagaki, Haruo

AU - Murohara, Toyoaki

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Aims: To evaluate the frequency, predictors and prognostic significance of elevation in cardiac troponin I (cTnI) after coronary angiography (CAG). Methods and results: A series of 296 consecutive patients with normal pre-procedural cTnI levels and undergoing elective CAG at our centre were prospectively analysed. Positive cTnI elevation was defined as >0.06 ng/ml. Positive cTnI elevation was observed in 44 patients (14.8%), but CK-MB was elevated in only four patients (1.3%) after the procedure. The risk of cTnI elevation was independently associated with left ventricular hypertrophy (odds ratio [OR] 5.52; 95% confidence interval [CI], 2.54 to 12.02; P<0.001), inexperienced operator (OR 10.83; 95% CI, 2.47 to 47.43; P=0.002) and the amount of contrast agent (OR 1.12; 95% CI, 1.03 to 1.23; P=0.009 for each 10 ml increase), whereas it was not associated with the severity of coronary artery disease. At one year, however, postprocedural elevation of cTnI was not associated with an increased risk of death (2.3% vs. 0.8%, P=0.384) or myocardial infarction (2.3% vs. 2.0%, P=0.623). Conclusions: A minor elevation of cTnI is observed commonly after CAG, which might be associated with left ventricular hypertrophy, operator's experience and the amount of contrast used; however, it does not influence 1-year events rates.

AB - Aims: To evaluate the frequency, predictors and prognostic significance of elevation in cardiac troponin I (cTnI) after coronary angiography (CAG). Methods and results: A series of 296 consecutive patients with normal pre-procedural cTnI levels and undergoing elective CAG at our centre were prospectively analysed. Positive cTnI elevation was defined as >0.06 ng/ml. Positive cTnI elevation was observed in 44 patients (14.8%), but CK-MB was elevated in only four patients (1.3%) after the procedure. The risk of cTnI elevation was independently associated with left ventricular hypertrophy (odds ratio [OR] 5.52; 95% confidence interval [CI], 2.54 to 12.02; P<0.001), inexperienced operator (OR 10.83; 95% CI, 2.47 to 47.43; P=0.002) and the amount of contrast agent (OR 1.12; 95% CI, 1.03 to 1.23; P=0.009 for each 10 ml increase), whereas it was not associated with the severity of coronary artery disease. At one year, however, postprocedural elevation of cTnI was not associated with an increased risk of death (2.3% vs. 0.8%, P=0.384) or myocardial infarction (2.3% vs. 2.0%, P=0.623). Conclusions: A minor elevation of cTnI is observed commonly after CAG, which might be associated with left ventricular hypertrophy, operator's experience and the amount of contrast used; however, it does not influence 1-year events rates.

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