Abstract
This review summarizes the effects of neuroinflammatory stress on the subventricular zone (SVZ), where new neurons are constitutively produced in the adult brain, especially focusing on the relation with Parkinson's disease (PD), because the SVZ is under the control of dopaminergic afferents from the substantia nigra (SN). In Lewy bodies-positive-PD, microglia is known to phagocytoze aggregated α-synuclein, resulting in the release of inflammatory cytokines. The neurogenesis in the SVZ should be affected in PD brain by the neuroinflammatory process. The administration of lipopolysaccaharide is available as an alternative model for microglia-induced loss of dopaminergic neurons and also the impairment of stem cell maintenance. Therefore, the research on the neuroinflammatory process in the SVZ gives us a hint to prevent the outbreak of PD or at least slow the disease process.
| Original language | English |
|---|---|
| Pages (from-to) | 777-785 |
| Number of pages | 9 |
| Journal | Cellular and molecular neurobiology |
| Volume | 32 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 01-07-2012 |
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All Science Journal Classification (ASJC) codes
- Cellular and Molecular Neuroscience
- Cell Biology
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Subventricular zone under the neuroinflammatory stress and Parkinson's disease. / Mori, Keiji; Kaneko, Yoko S.; Nakashima, Akira; Nagasaki, Hiroshi; Nagatsu, Toshiharu; Nagatsu, Ikuko; Ota, Akira.
In: Cellular and molecular neurobiology, Vol. 32, No. 5, 01.07.2012, p. 777-785.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Subventricular zone under the neuroinflammatory stress and Parkinson's disease
AU - Mori, Keiji
AU - Kaneko, Yoko S.
AU - Nakashima, Akira
AU - Nagasaki, Hiroshi
AU - Nagatsu, Toshiharu
AU - Nagatsu, Ikuko
AU - Ota, Akira
PY - 2012/7/1
Y1 - 2012/7/1
N2 - This review summarizes the effects of neuroinflammatory stress on the subventricular zone (SVZ), where new neurons are constitutively produced in the adult brain, especially focusing on the relation with Parkinson's disease (PD), because the SVZ is under the control of dopaminergic afferents from the substantia nigra (SN). In Lewy bodies-positive-PD, microglia is known to phagocytoze aggregated α-synuclein, resulting in the release of inflammatory cytokines. The neurogenesis in the SVZ should be affected in PD brain by the neuroinflammatory process. The administration of lipopolysaccaharide is available as an alternative model for microglia-induced loss of dopaminergic neurons and also the impairment of stem cell maintenance. Therefore, the research on the neuroinflammatory process in the SVZ gives us a hint to prevent the outbreak of PD or at least slow the disease process.
AB - This review summarizes the effects of neuroinflammatory stress on the subventricular zone (SVZ), where new neurons are constitutively produced in the adult brain, especially focusing on the relation with Parkinson's disease (PD), because the SVZ is under the control of dopaminergic afferents from the substantia nigra (SN). In Lewy bodies-positive-PD, microglia is known to phagocytoze aggregated α-synuclein, resulting in the release of inflammatory cytokines. The neurogenesis in the SVZ should be affected in PD brain by the neuroinflammatory process. The administration of lipopolysaccaharide is available as an alternative model for microglia-induced loss of dopaminergic neurons and also the impairment of stem cell maintenance. Therefore, the research on the neuroinflammatory process in the SVZ gives us a hint to prevent the outbreak of PD or at least slow the disease process.
UR - http://www.scopus.com/inward/record.url?scp=84864684056&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864684056&partnerID=8YFLogxK
U2 - 10.1007/s10571-011-9783-1
DO - 10.1007/s10571-011-9783-1
M3 - Review article
C2 - 22189676
AN - SCOPUS:84864684056
VL - 32
SP - 777
EP - 785
JO - Cellular and Molecular Neurobiology
JF - Cellular and Molecular Neurobiology
SN - 0272-4340
IS - 5
ER -