Subventricular zone under the neuroinflammatory stress and Parkinson's disease

Keiji Mori, Yoko S. Kaneko, Akira Nakashima, Hiroshi Nagasaki, Toshiharu Nagatsu, Ikuko Nagatsu, Akira Ota

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

This review summarizes the effects of neuroinflammatory stress on the subventricular zone (SVZ), where new neurons are constitutively produced in the adult brain, especially focusing on the relation with Parkinson's disease (PD), because the SVZ is under the control of dopaminergic afferents from the substantia nigra (SN). In Lewy bodies-positive-PD, microglia is known to phagocytoze aggregated α-synuclein, resulting in the release of inflammatory cytokines. The neurogenesis in the SVZ should be affected in PD brain by the neuroinflammatory process. The administration of lipopolysaccaharide is available as an alternative model for microglia-induced loss of dopaminergic neurons and also the impairment of stem cell maintenance. Therefore, the research on the neuroinflammatory process in the SVZ gives us a hint to prevent the outbreak of PD or at least slow the disease process.

Original languageEnglish
Pages (from-to)777-785
Number of pages9
JournalCellular and molecular neurobiology
Volume32
Issue number5
DOIs
Publication statusPublished - 01-07-2012

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All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology

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