Successful Conversion Therapy for Gastric Cancer with Paraaortic Lymph Node Metastasis after SP Therapy-A Case Report

Yuko Nakano, Ai Goto, Kenji Kikuchi, Kazumitsu Suzuki, Kazuhiro Matsuo, Yasuhiro Tsuru, Kenichi Nakamura, Susumu Shibasaki, Koichi Suda, Kazuki Inaba, Tsunekazu Hanai, Yutaro Kato, Atsushi Sugioka, Ichiro Uyama

Research output: Contribution to journalArticlepeer-review

Abstract

A 69-year-old woman, who complained of loss of appetite, was admitted to our hospital and diagnosed with clinical Stage Ⅳgastric cancer and paraaortic lymph node metastases(cT4aN3M1[#16b1LYM], cStage Ⅳ). She underwent 2 cycles of SP therapy(combination of S-1 and CDDP). A partial response of the primary tumor was noted, with no distant metastases, except for the paraaortic lymph nodes. She underwent robotic total gastrectomy with D2 plus paraaortic lymph node dissection. Histopathology showed no residual tumor cells in the stomach or lymph nodes. Postoperatively, the patient underwent 3 cycles of SOX therapy(combination of S-1 and oxaliplatin)and survived for over 6 postoperative months, with no recurrences. For advanced gastric cancers with paraaortic lymph node dissection with no evidences of other distant metastases, gastrectomy with paraaortic lymph node dissection combined with chemotherapy could be a therapeutic option to achieve R0 resection.

Original languageEnglish
Pages (from-to)2539-2541
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume46
Issue number13
Publication statusPublished - 01-12-2019

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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