TY - JOUR
T1 - Successful management of rocuronium-induced anaphylactic reactions with sugammadex
T2 - A case report
AU - Kawano, Takashi
AU - Tamura, Takahiko
AU - Hamaguchi, Mayuko
AU - Yatabe, Tomoaki
AU - Yamashita, Koichi
AU - Yokoyama, Masataka
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/2
Y1 - 2012/2
N2 - Sugammadex, a new reversal agent for rocuronium, encapsulates the rocuronium molecule and results in rapid reversal of rocuronium-induced neuromuscular blockade. A case in which sugammadex was used to treat an anaphylactic reaction that occurred after rocuronium is presented. The binding/encapsulation of rocuronium by sugammadex may selectively eliminate the antigenic quaternary ammonium activity of circulating rocuronium, and prevent the propagation of rocuronium-induced anaphylaxis.
AB - Sugammadex, a new reversal agent for rocuronium, encapsulates the rocuronium molecule and results in rapid reversal of rocuronium-induced neuromuscular blockade. A case in which sugammadex was used to treat an anaphylactic reaction that occurred after rocuronium is presented. The binding/encapsulation of rocuronium by sugammadex may selectively eliminate the antigenic quaternary ammonium activity of circulating rocuronium, and prevent the propagation of rocuronium-induced anaphylaxis.
UR - http://www.scopus.com/inward/record.url?scp=84856354320&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856354320&partnerID=8YFLogxK
U2 - 10.1016/j.jclinane.2011.04.015
DO - 10.1016/j.jclinane.2011.04.015
M3 - Article
C2 - 22154092
AN - SCOPUS:84856354320
SN - 0952-8180
VL - 24
SP - 62
EP - 64
JO - Journal of Clinical Anesthesia
JF - Journal of Clinical Anesthesia
IS - 1
ER -