Successful management of rocuronium-induced anaphylactic reactions with sugammadex: A case report

Takashi Kawano; Takahiko Tamura; Mayuko Hamaguchi; Tomoaki Yatabe; Koichi Yamashita; Masataka Yokoyama

doi:10.1016/j.jclinane.2011.04.015

Successful management of rocuronium-induced anaphylactic reactions with sugammadex: A case report

Takashi Kawano
, Takahiko Tamura
, Mayuko Hamaguchi
, Tomoaki Yatabe
, Koichi Yamashita
, Masataka Yokoyama

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Sugammadex, a new reversal agent for rocuronium, encapsulates the rocuronium molecule and results in rapid reversal of rocuronium-induced neuromuscular blockade. A case in which sugammadex was used to treat an anaphylactic reaction that occurred after rocuronium is presented. The binding/encapsulation of rocuronium by sugammadex may selectively eliminate the antigenic quaternary ammonium activity of circulating rocuronium, and prevent the propagation of rocuronium-induced anaphylaxis.

Original language	English
Pages (from-to)	62-64
Number of pages	3
Journal	Journal of Clinical Anesthesia
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.jclinane.2011.04.015
Publication status	Published - 02-2012

All Science Journal Classification (ASJC) codes

Anesthesiology and Pain Medicine

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10.1016/j.jclinane.2011.04.015

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AU - Yatabe, Tomoaki

AU - Yamashita, Koichi

AU - Yokoyama, Masataka

PY - 2012/2

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AB - Sugammadex, a new reversal agent for rocuronium, encapsulates the rocuronium molecule and results in rapid reversal of rocuronium-induced neuromuscular blockade. A case in which sugammadex was used to treat an anaphylactic reaction that occurred after rocuronium is presented. The binding/encapsulation of rocuronium by sugammadex may selectively eliminate the antigenic quaternary ammonium activity of circulating rocuronium, and prevent the propagation of rocuronium-induced anaphylaxis.

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Successful management of rocuronium-induced anaphylactic reactions with sugammadex: A case report

Abstract

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