Successful pregnancy in a patient with chronic myeloid leukemia under treatment with imatinib

Motohiro Tsuzuki, Youko Inaguma, Kousuke Handa, Akio Hasegawa, Yukiya Yamamoto, Masato Watanabe, Syuichi Mizuta, Fumio Maruyama, Masataka Okamoto, Nobuhiko Emi

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4 Citations (Scopus)

Abstract

Contraception is recommended during imatinib therapy based on the teratogenicity data in rats. However, patients may become pregnant and here we describe a successful pregnancy and labor without any congenital anomaly in a patient with chronic myeloid leukemia (CML) under treatment with imatinib. The patient had received imatinib for 53 months before she became pregnant, with a complete cytogenetic response achieved after 6 months of therapy and a major molecular response (MMR) after 28 months. CML was in MMR at discovery of pregnancy and the fetus had been exposed to imatinib for 5 weeks. Treatment was discontinued, but MMR persisted during gestation.

Original languageEnglish
Pages (from-to)1433-1435
Number of pages3
JournalInternal Medicine
Volume48
Issue number16
DOIs
Publication statusPublished - 05-10-2009

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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    Tsuzuki, M., Inaguma, Y., Handa, K., Hasegawa, A., Yamamoto, Y., Watanabe, M., Mizuta, S., Maruyama, F., Okamoto, M., & Emi, N. (2009). Successful pregnancy in a patient with chronic myeloid leukemia under treatment with imatinib. Internal Medicine, 48(16), 1433-1435. https://doi.org/10.2169/internalmedicine.48.2084