Successful prevention of hematological relapse for a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic bone marrow transplantation by donor leukocyte infusion

M. Yazaki, M. Andoh, Tetsuya Ito, T. Ohno, Y. Wada

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27 Citations (Scopus)

Abstract

Donor leukocyte infusion (DLI) was carried out on a 12-year-old girl with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) who received allogeneic bone marrow transplantation from an HLA-identical sibling. This is the first report of DLI use before the onset of hematological relapse monitored by the results of RT-PCR. This patient has been in CR for 11 months after BMT, suggesting this alternative treatment is promising for Ph + ALL with positive reverse transcriptase-polymerase chain reaction (RT-PCR) following BMT.

Original languageEnglish
Pages (from-to)393-394
Number of pages2
JournalBone Marrow Transplantation
Volume19
Issue number4
DOIs
Publication statusPublished - 02-02-1997

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Philadelphia Chromosome
Homologous Transplantation
Secondary Prevention
Reverse Transcriptase Polymerase Chain Reaction
Bone Marrow Transplantation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukocytes
Tissue Donors
Siblings
Recurrence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this

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abstract = "Donor leukocyte infusion (DLI) was carried out on a 12-year-old girl with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) who received allogeneic bone marrow transplantation from an HLA-identical sibling. This is the first report of DLI use before the onset of hematological relapse monitored by the results of RT-PCR. This patient has been in CR for 11 months after BMT, suggesting this alternative treatment is promising for Ph + ALL with positive reverse transcriptase-polymerase chain reaction (RT-PCR) following BMT.",
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T1 - Successful prevention of hematological relapse for a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic bone marrow transplantation by donor leukocyte infusion

AU - Yazaki, M.

AU - Andoh, M.

AU - Ito, Tetsuya

AU - Ohno, T.

AU - Wada, Y.

PY - 1997/2/2

Y1 - 1997/2/2

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AB - Donor leukocyte infusion (DLI) was carried out on a 12-year-old girl with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) who received allogeneic bone marrow transplantation from an HLA-identical sibling. This is the first report of DLI use before the onset of hematological relapse monitored by the results of RT-PCR. This patient has been in CR for 11 months after BMT, suggesting this alternative treatment is promising for Ph + ALL with positive reverse transcriptase-polymerase chain reaction (RT-PCR) following BMT.

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