Successful treatment of advanced gastric adenocarcinoma with portal tumor thrombosis by total gastrectomy following CDDP and S-1 therapy

Sumiya Ishigami, Takaaki Arigami, Keishi Okubo, Ken Sasaki, Hiroshi Kurahara, Yoshikazu Uenosono, Hiroshi Okumura, Tetsuhiro Owaki, Yuko Kijima, Shinichi Ueno, Shoji Natsugoe

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Gastric cancers with portal tumor thrombosis (GCPTs) are a rare entity, often concomitant with hematogenous metastases, and chemotherapy is mainly used to treat them. However, the outcome of GCPT is reported to be dismal. We experienced a case of GCPT with splenic metastases. A 53-year-old man was admitted for anorexia. Upper gastrointestinal scope revealed type 3 gastric cancer of the stomach. Abdominal computed tomography showed a huge tumor thrombus in the splenic vein extending to the hepatic hilus and multiple metastases to the spleen. S-1 was given orally from day 1 to day 21 and 60 mg of CDDP was administered intravenously. The cancerous thrombosis in the portal system and splenic metastases disappeared due to chemotherapy. Total gastrectomy with lymphadenectomy and splenectomy was carried out with curative intent after 10 courses of chemotherapy. Intraoperatively, no tumor thrombosis was identified and the gastric tumor was surgically removed. After surgery, the patient received adjuvant chemotherapy of S-1. After 6 months he is well and has not suffered from tumor relapse. A combination of CDDP ? S-1 plus intervention surgery seems to be a promising option for GCPT.

Original languageEnglish
Pages (from-to)230-233
Number of pages4
JournalClinical Journal of Gastroenterology
Volume5
Issue number3
DOIs
Publication statusPublished - 01-06-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Fingerprint Dive into the research topics of 'Successful treatment of advanced gastric adenocarcinoma with portal tumor thrombosis by total gastrectomy following CDDP and S-1 therapy'. Together they form a unique fingerprint.

Cite this