Successful treatment of partial nephrogenic diabetes insipidus with thiazide and desmopressin

Haruo Mizuno, Shinji Fujimoto, Yukari Sugiyama, Masanori Kobayashi, Yoichiro Ohro, Shinichi Uchida, Sei Sasaki, Hajime Togari

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Objective: To clarify whether combination treatment with desmopressin (DDAVP) and thiazide was clinically effective in a patient with congenital nephrogenic diabetes insipidus (CNDI), we evaluated the treatment in a 7-year-old boy with CNDI who had demonstrated a partial response to DDAVP. Method: Both volume of urine and the presence of nocturia were determined during treatment. Result: Neither the usual therapy of a low-salt diet and a thiazide nor intranasal therapy with a large dose of DDAVP was effective. However, combination treatment resulted in a decrease in urinary volume and the disappearance of nocturia. Conclusion: DDAVP coupled with thiazide may be useful for CNDI in patients who have shown a partial response to DDAVP.

Original languageEnglish
Pages (from-to)297-300
Number of pages4
JournalHormone Research
Issue number6
Publication statusPublished - 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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