Successful treatment of partial nephrogenic diabetes insipidus with thiazide and desmopressin

Haruo Mizuno; Shinji Fujimoto; Yukari Sugiyama; Masanori Kobayashi; Yoichiro Ohro; Shinichi Uchida; Sei Sasaki; Hajime Togari

doi:10.1159/000070629

Successful treatment of partial nephrogenic diabetes insipidus with thiazide and desmopressin

Haruo Mizuno, Shinji Fujimoto, Yukari Sugiyama, Masanori Kobayashi, Yoichiro Ohro, Shinichi Uchida, Sei Sasaki, Hajime Togari

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Objective: To clarify whether combination treatment with desmopressin (DDAVP) and thiazide was clinically effective in a patient with congenital nephrogenic diabetes insipidus (CNDI), we evaluated the treatment in a 7-year-old boy with CNDI who had demonstrated a partial response to DDAVP. Method: Both volume of urine and the presence of nocturia were determined during treatment. Result: Neither the usual therapy of a low-salt diet and a thiazide nor intranasal therapy with a large dose of DDAVP was effective. However, combination treatment resulted in a decrease in urinary volume and the disappearance of nocturia. Conclusion: DDAVP coupled with thiazide may be useful for CNDI in patients who have shown a partial response to DDAVP.

Original language	English
Pages (from-to)	297-300
Number of pages	4
Journal	Hormone Research
Volume	59
Issue number	6
DOIs	https://doi.org/10.1159/000070629
Publication status	Published - 2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1159/000070629

Cite this

@article{a87c8faca9c94f2083042e4c58e09fff,

title = "Successful treatment of partial nephrogenic diabetes insipidus with thiazide and desmopressin",

abstract = "Objective: To clarify whether combination treatment with desmopressin (DDAVP) and thiazide was clinically effective in a patient with congenital nephrogenic diabetes insipidus (CNDI), we evaluated the treatment in a 7-year-old boy with CNDI who had demonstrated a partial response to DDAVP. Method: Both volume of urine and the presence of nocturia were determined during treatment. Result: Neither the usual therapy of a low-salt diet and a thiazide nor intranasal therapy with a large dose of DDAVP was effective. However, combination treatment resulted in a decrease in urinary volume and the disappearance of nocturia. Conclusion: DDAVP coupled with thiazide may be useful for CNDI in patients who have shown a partial response to DDAVP.",

keywords = "Congenital nephrogenic insipidus, Desmopressin, Thiazide",

author = "Haruo Mizuno and Shinji Fujimoto and Yukari Sugiyama and Masanori Kobayashi and Yoichiro Ohro and Shinichi Uchida and Sei Sasaki and Hajime Togari",

year = "2003",

doi = "10.1159/000070629",

language = "English",

volume = "59",

pages = "297--300",

journal = "Hormone Research",

issn = "0301-0163",

publisher = "S. Karger AG",

number = "6",

}

TY - JOUR

T1 - Successful treatment of partial nephrogenic diabetes insipidus with thiazide and desmopressin

AU - Mizuno, Haruo

AU - Fujimoto, Shinji

AU - Sugiyama, Yukari

AU - Kobayashi, Masanori

AU - Ohro, Yoichiro

AU - Uchida, Shinichi

AU - Sasaki, Sei

AU - Togari, Hajime

PY - 2003

Y1 - 2003

N2 - Objective: To clarify whether combination treatment with desmopressin (DDAVP) and thiazide was clinically effective in a patient with congenital nephrogenic diabetes insipidus (CNDI), we evaluated the treatment in a 7-year-old boy with CNDI who had demonstrated a partial response to DDAVP. Method: Both volume of urine and the presence of nocturia were determined during treatment. Result: Neither the usual therapy of a low-salt diet and a thiazide nor intranasal therapy with a large dose of DDAVP was effective. However, combination treatment resulted in a decrease in urinary volume and the disappearance of nocturia. Conclusion: DDAVP coupled with thiazide may be useful for CNDI in patients who have shown a partial response to DDAVP.

AB - Objective: To clarify whether combination treatment with desmopressin (DDAVP) and thiazide was clinically effective in a patient with congenital nephrogenic diabetes insipidus (CNDI), we evaluated the treatment in a 7-year-old boy with CNDI who had demonstrated a partial response to DDAVP. Method: Both volume of urine and the presence of nocturia were determined during treatment. Result: Neither the usual therapy of a low-salt diet and a thiazide nor intranasal therapy with a large dose of DDAVP was effective. However, combination treatment resulted in a decrease in urinary volume and the disappearance of nocturia. Conclusion: DDAVP coupled with thiazide may be useful for CNDI in patients who have shown a partial response to DDAVP.

KW - Congenital nephrogenic insipidus

KW - Desmopressin

KW - Thiazide

UR - http://www.scopus.com/inward/record.url?scp=0037679062&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037679062&partnerID=8YFLogxK

U2 - 10.1159/000070629

DO - 10.1159/000070629

M3 - Article

C2 - 12784095

AN - SCOPUS:0037679062

SN - 0301-0163

VL - 59

SP - 297

EP - 300

JO - Hormone Research

JF - Hormone Research

IS - 6

ER -

Successful treatment of partial nephrogenic diabetes insipidus with thiazide and desmopressin

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this