11C-methionine- and 18F-FDG-PET double-negative metastatic brain tumor from lung adenocarcinoma with paradoxical high 18F-FDG uptake: A case report

Kuniaki Tanahashi; Masaki Hirano; Lushun Chalise; Takahiko Tsugawa; Yuka Okumura; Tetsunari Hase; Fumiharu Ohka; Kazuya Motomura; Kazuhito Takeuchi; Yuichi Nagata; Norimoto Nakahara; Naozumi Hashimoto; Ryuta Saito

doi:10.25259/SNI_264_2022

¹¹C-methionine- and ¹⁸F-FDG-PET double-negative metastatic brain tumor from lung adenocarcinoma with paradoxical high ¹⁸F-FDG uptake: A case report

Kuniaki Tanahashi, Masaki Hirano, Lushun Chalise, Takahiko Tsugawa, Yuka Okumura, Tetsunari Hase, Fumiharu Ohka, Kazuya Motomura, Kazuhito Takeuchi, Yuichi Nagata, Norimoto Nakahara, Naozumi Hashimoto, Ryuta Saito

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Imaging with ¹⁸F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) and ¹¹C-methionine (MET)-PET can delineate primary and metastatic brain tumors. Lesion size affects the sensitivity of both scans and histopathological features can also influence FDG-PET, but the effects on MET-PET have not been elucidated. Case Description: We report an unusual case of metastatic brain tumors without accumulation of FDG or MET, contrasting with high FDG uptake in the primary lung lesion. The brain lesions were identified as adenocarcinoma with a more mucus-rich background, contributing to the indistinct accumulation of both FDG and MET. Conclusion: Histopathological characteristics can affect both MET and FDG accumulation, leading to findings contradicting those of the primary lesion.

Original language	English
Article number	2642022
Journal	Surgical Neurology International
Volume	13
DOIs	https://doi.org/10.25259/SNI_264_2022
Publication status	Published - 2022
Externally published	Yes

All Science Journal Classification (ASJC) codes

Surgery
Clinical Neurology

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Tanahashi, K., Hirano, M., Chalise, L., Tsugawa, T., Okumura, Y., Hase, T., Ohka, F., Motomura, K., Takeuchi, K., Nagata, Y., Nakahara, N., Hashimoto, N., & Saito, R. (2022). ¹¹C-methionine- and ¹⁸F-FDG-PET double-negative metastatic brain tumor from lung adenocarcinoma with paradoxical high ¹⁸F-FDG uptake: A case report. Surgical Neurology International, 13, Article 2642022. https://doi.org/10.25259/SNI_264_2022

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title = "11C-methionine- and 18F-FDG-PET double-negative metastatic brain tumor from lung adenocarcinoma with paradoxical high 18F-FDG uptake: A case report",

abstract = "Background: Imaging with 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) and 11C-methionine (MET)-PET can delineate primary and metastatic brain tumors. Lesion size affects the sensitivity of both scans and histopathological features can also influence FDG-PET, but the effects on MET-PET have not been elucidated. Case Description: We report an unusual case of metastatic brain tumors without accumulation of FDG or MET, contrasting with high FDG uptake in the primary lung lesion. The brain lesions were identified as adenocarcinoma with a more mucus-rich background, contributing to the indistinct accumulation of both FDG and MET. Conclusion: Histopathological characteristics can affect both MET and FDG accumulation, leading to findings contradicting those of the primary lesion.",

author = "Kuniaki Tanahashi and Masaki Hirano and Lushun Chalise and Takahiko Tsugawa and Yuka Okumura and Tetsunari Hase and Fumiharu Ohka and Kazuya Motomura and Kazuhito Takeuchi and Yuichi Nagata and Norimoto Nakahara and Naozumi Hashimoto and Ryuta Saito",

year = "2022",

doi = "10.25259/SNI_264_2022",

language = "English",

volume = "13",

journal = "Surgical Neurology International",

issn = "2152-7806",

publisher = "Scientific Scholar LLC",

}

Tanahashi, K, Hirano, M, Chalise, L, Tsugawa, T, Okumura, Y, Hase, T, Ohka, F, Motomura, K, Takeuchi, K, Nagata, Y, Nakahara, N, Hashimoto, N & Saito, R 2022, '¹¹C-methionine- and ¹⁸F-FDG-PET double-negative metastatic brain tumor from lung adenocarcinoma with paradoxical high ¹⁸F-FDG uptake: A case report', Surgical Neurology International, vol. 13, 2642022. https://doi.org/10.25259/SNI_264_2022

TY - JOUR

T1 - 11C-methionine- and 18F-FDG-PET double-negative metastatic brain tumor from lung adenocarcinoma with paradoxical high 18F-FDG uptake

T2 - A case report

AU - Tanahashi, Kuniaki

AU - Hirano, Masaki

AU - Chalise, Lushun

AU - Tsugawa, Takahiko

AU - Okumura, Yuka

AU - Hase, Tetsunari

AU - Ohka, Fumiharu

AU - Motomura, Kazuya

AU - Takeuchi, Kazuhito

AU - Nagata, Yuichi

AU - Nakahara, Norimoto

AU - Hashimoto, Naozumi

AU - Saito, Ryuta

PY - 2022

Y1 - 2022

N2 - Background: Imaging with 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) and 11C-methionine (MET)-PET can delineate primary and metastatic brain tumors. Lesion size affects the sensitivity of both scans and histopathological features can also influence FDG-PET, but the effects on MET-PET have not been elucidated. Case Description: We report an unusual case of metastatic brain tumors without accumulation of FDG or MET, contrasting with high FDG uptake in the primary lung lesion. The brain lesions were identified as adenocarcinoma with a more mucus-rich background, contributing to the indistinct accumulation of both FDG and MET. Conclusion: Histopathological characteristics can affect both MET and FDG accumulation, leading to findings contradicting those of the primary lesion.

AB - Background: Imaging with 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) and 11C-methionine (MET)-PET can delineate primary and metastatic brain tumors. Lesion size affects the sensitivity of both scans and histopathological features can also influence FDG-PET, but the effects on MET-PET have not been elucidated. Case Description: We report an unusual case of metastatic brain tumors without accumulation of FDG or MET, contrasting with high FDG uptake in the primary lung lesion. The brain lesions were identified as adenocarcinoma with a more mucus-rich background, contributing to the indistinct accumulation of both FDG and MET. Conclusion: Histopathological characteristics can affect both MET and FDG accumulation, leading to findings contradicting those of the primary lesion.

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DO - 10.25259/SNI_264_2022

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JO - Surgical Neurology International

JF - Surgical Neurology International

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ER -

¹¹C-methionine- and ¹⁸F-FDG-PET double-negative metastatic brain tumor from lung adenocarcinoma with paradoxical high ¹⁸F-FDG uptake: A case report

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