11C-methionine- and 18F-FDG-PET double-negative metastatic brain tumor from lung adenocarcinoma with paradoxical high 18F-FDG uptake: A case report

Kuniaki Tanahashi, Masaki Hirano, Lushun Chalise, Takahiko Tsugawa, Yuka Okumura, Tetsunari Hase, Fumiharu Ohka, Kazuya Motomura, Kazuhito Takeuchi, Yuichi Nagata, Norimoto Nakahara, Naozumi Hashimoto, Ryuta Saito

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Imaging with 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) and 11C-methionine (MET)-PET can delineate primary and metastatic brain tumors. Lesion size affects the sensitivity of both scans and histopathological features can also influence FDG-PET, but the effects on MET-PET have not been elucidated. Case Description: We report an unusual case of metastatic brain tumors without accumulation of FDG or MET, contrasting with high FDG uptake in the primary lung lesion. The brain lesions were identified as adenocarcinoma with a more mucus-rich background, contributing to the indistinct accumulation of both FDG and MET. Conclusion: Histopathological characteristics can affect both MET and FDG accumulation, leading to findings contradicting those of the primary lesion.

Original languageEnglish
Article number2642022
JournalSurgical Neurology International
Volume13
DOIs
Publication statusPublished - 2022
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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