18F-FDG PET for semiquantitative evaluation of acute allograft rejection and immunosuppressive therapy efficacy in rat models of liver transplantation

Atsushi B. Tsuji, Miwa Morita, Xiao Kang Li, Chizuru Sogawa, Hitomi Sudo, Aya Sugyo, Masayuki Fujino, Atsushi Sugioka, Mitsuru Koizumi, Tsuneo Saga

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17 Citations (Scopus)

Abstract

Acute allograft rejection remains a major complication after liver transplantation. We report a semiquantitative imaging method of detecting acute allograft rejection with 18F-FDG PET. Methods: Syngeneic and allogeneic transplanted rats, with or without immunosuppressive treatment, were subjected to serial PET. Autoradiography of the liver was conducted in both the syngeneic and the allogeneic rats. Results: A significant increment of 18F-FDG accumulation in liver allografts was observed by PET on day 2. The 18F-FDG signal was concentrated in the area where inflammatory cells around the vessels were detected by autoradiography. Allotransplanted rats treated with an immunosuppressive agent displayed a marked decrease in hepatic 18F-FDG uptake, compared with allotransplanted rats that were not treated. Conclusion: 18F-FDG PET may be a valid method for facilitating the development of protocols to diagnose graft rejection and to monitor the efficacy of immunosuppressive therapy.

Original languageEnglish
Pages (from-to)827-830
Number of pages4
JournalJournal of Nuclear Medicine
Volume50
Issue number5
DOIs
Publication statusPublished - 01-05-2009

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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