18F-FDG PET for semiquantitative evaluation of acute allograft rejection and immunosuppressive therapy efficacy in rat models of liver transplantation

Atsushi B. Tsuji; Miwa Morita; Xiao Kang Li; Chizuru Sogawa; Hitomi Sudo; Aya Sugyo; Masayuki Fujino; Atsushi Sugioka; Mitsuru Koizumi; Tsuneo Saga

doi:10.2967/jnumed.108.058925

¹⁸F-FDG PET for semiquantitative evaluation of acute allograft rejection and immunosuppressive therapy efficacy in rat models of liver transplantation

Atsushi B. Tsuji
, Miwa Morita
, Xiao Kang Li
, Chizuru Sogawa
, Hitomi Sudo
, Aya Sugyo
, Masayuki Fujino
, Atsushi Sugioka
, Mitsuru Koizumi
, Tsuneo Saga

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Acute allograft rejection remains a major complication after liver transplantation. We report a semiquantitative imaging method of detecting acute allograft rejection with ¹⁸F-FDG PET. Methods: Syngeneic and allogeneic transplanted rats, with or without immunosuppressive treatment, were subjected to serial PET. Autoradiography of the liver was conducted in both the syngeneic and the allogeneic rats. Results: A significant increment of ¹⁸F-FDG accumulation in liver allografts was observed by PET on day 2. The ¹⁸F-FDG signal was concentrated in the area where inflammatory cells around the vessels were detected by autoradiography. Allotransplanted rats treated with an immunosuppressive agent displayed a marked decrease in hepatic ¹⁸F-FDG uptake, compared with allotransplanted rats that were not treated. Conclusion: ¹⁸F-FDG PET may be a valid method for facilitating the development of protocols to diagnose graft rejection and to monitor the efficacy of immunosuppressive therapy.

Original language	English
Pages (from-to)	827-830
Number of pages	4
Journal	Journal of Nuclear Medicine
Volume	50
Issue number	5
DOIs	https://doi.org/10.2967/jnumed.108.058925
Publication status	Published - 01-05-2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

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10.2967/jnumed.108.058925

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title = "18F-FDG PET for semiquantitative evaluation of acute allograft rejection and immunosuppressive therapy efficacy in rat models of liver transplantation",

abstract = "Acute allograft rejection remains a major complication after liver transplantation. We report a semiquantitative imaging method of detecting acute allograft rejection with 18F-FDG PET. Methods: Syngeneic and allogeneic transplanted rats, with or without immunosuppressive treatment, were subjected to serial PET. Autoradiography of the liver was conducted in both the syngeneic and the allogeneic rats. Results: A significant increment of 18F-FDG accumulation in liver allografts was observed by PET on day 2. The 18F-FDG signal was concentrated in the area where inflammatory cells around the vessels were detected by autoradiography. Allotransplanted rats treated with an immunosuppressive agent displayed a marked decrease in hepatic 18F-FDG uptake, compared with allotransplanted rats that were not treated. Conclusion: 18F-FDG PET may be a valid method for facilitating the development of protocols to diagnose graft rejection and to monitor the efficacy of immunosuppressive therapy.",

author = "Tsuji, \{Atsushi B.\} and Miwa Morita and Li, \{Xiao Kang\} and Chizuru Sogawa and Hitomi Sudo and Aya Sugyo and Masayuki Fujino and Atsushi Sugioka and Mitsuru Koizumi and Tsuneo Saga",

year = "2009",

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doi = "10.2967/jnumed.108.058925",

language = "English",

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TY - JOUR

T1 - 18F-FDG PET for semiquantitative evaluation of acute allograft rejection and immunosuppressive therapy efficacy in rat models of liver transplantation

AU - Tsuji, Atsushi B.

AU - Morita, Miwa

AU - Li, Xiao Kang

AU - Sogawa, Chizuru

AU - Sudo, Hitomi

AU - Sugyo, Aya

AU - Fujino, Masayuki

AU - Sugioka, Atsushi

AU - Koizumi, Mitsuru

AU - Saga, Tsuneo

PY - 2009/5/1

Y1 - 2009/5/1

N2 - Acute allograft rejection remains a major complication after liver transplantation. We report a semiquantitative imaging method of detecting acute allograft rejection with 18F-FDG PET. Methods: Syngeneic and allogeneic transplanted rats, with or without immunosuppressive treatment, were subjected to serial PET. Autoradiography of the liver was conducted in both the syngeneic and the allogeneic rats. Results: A significant increment of 18F-FDG accumulation in liver allografts was observed by PET on day 2. The 18F-FDG signal was concentrated in the area where inflammatory cells around the vessels were detected by autoradiography. Allotransplanted rats treated with an immunosuppressive agent displayed a marked decrease in hepatic 18F-FDG uptake, compared with allotransplanted rats that were not treated. Conclusion: 18F-FDG PET may be a valid method for facilitating the development of protocols to diagnose graft rejection and to monitor the efficacy of immunosuppressive therapy.

AB - Acute allograft rejection remains a major complication after liver transplantation. We report a semiquantitative imaging method of detecting acute allograft rejection with 18F-FDG PET. Methods: Syngeneic and allogeneic transplanted rats, with or without immunosuppressive treatment, were subjected to serial PET. Autoradiography of the liver was conducted in both the syngeneic and the allogeneic rats. Results: A significant increment of 18F-FDG accumulation in liver allografts was observed by PET on day 2. The 18F-FDG signal was concentrated in the area where inflammatory cells around the vessels were detected by autoradiography. Allotransplanted rats treated with an immunosuppressive agent displayed a marked decrease in hepatic 18F-FDG uptake, compared with allotransplanted rats that were not treated. Conclusion: 18F-FDG PET may be a valid method for facilitating the development of protocols to diagnose graft rejection and to monitor the efficacy of immunosuppressive therapy.

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DO - 10.2967/jnumed.108.058925

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AN - SCOPUS:66149092752

SN - 0161-5505

VL - 50

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JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

IS - 5

ER -

¹⁸F-FDG PET for semiquantitative evaluation of acute allograft rejection and immunosuppressive therapy efficacy in rat models of liver transplantation

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