18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies

X. S. Hu; N. Okamura; Hiroyuki Arai; M. Higuchi; T. Matsui; M. Tashiro; M. Shinkawa; M. Itoh; T. Ido; H. Sasaki

doi:10.1212/wnl.55.10.1575

¹⁸F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies

X. S. Hu, N. Okamura, Hiroyuki Arai, M. Higuchi, T. Matsui, M. Tashiro, M. Shinkawa, M. Itoh, T. Ido, H. Sasaki

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

Using ¹⁸F-fluorodopa PET and a constant 0.0062 influx rate in the putamen, dementia with Lewy bodies (n = 7) was distinguished from AD (n = 10) with a sensitivity of 86% and a specificity of 100%. A constant 0.0071 influx rate in the caudate yielded a sensitivity of 71% and a specificity of 100% for distinction of the two disorders. Despite a limited sample size, these findings suggest that assessing nigrostriatal dopaminergic function with ¹⁸F-fluorodopa PET may be a useful diagnostic aid in cases of dementia with Lewy bodies while patients are alive.

Original language	English
Pages (from-to)	1575-1576
Number of pages	2
Journal	Neurology
Volume	55
Issue number	10
DOIs	https://doi.org/10.1212/wnl.55.10.1575
Publication status	Published - 28-11-2000
Externally published	Yes

All Science Journal Classification (ASJC) codes

Clinical Neurology

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abstract = "Using 18F-fluorodopa PET and a constant 0.0062 influx rate in the putamen, dementia with Lewy bodies (n = 7) was distinguished from AD (n = 10) with a sensitivity of 86% and a specificity of 100%. A constant 0.0071 influx rate in the caudate yielded a sensitivity of 71% and a specificity of 100% for distinction of the two disorders. Despite a limited sample size, these findings suggest that assessing nigrostriatal dopaminergic function with 18F-fluorodopa PET may be a useful diagnostic aid in cases of dementia with Lewy bodies while patients are alive.",

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T1 - 18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies

AU - Hu, X. S.

AU - Okamura, N.

AU - Arai, Hiroyuki

AU - Higuchi, M.

AU - Matsui, T.

AU - Tashiro, M.

AU - Shinkawa, M.

AU - Itoh, M.

AU - Ido, T.

AU - Sasaki, H.

PY - 2000/11/28

Y1 - 2000/11/28

N2 - Using 18F-fluorodopa PET and a constant 0.0062 influx rate in the putamen, dementia with Lewy bodies (n = 7) was distinguished from AD (n = 10) with a sensitivity of 86% and a specificity of 100%. A constant 0.0071 influx rate in the caudate yielded a sensitivity of 71% and a specificity of 100% for distinction of the two disorders. Despite a limited sample size, these findings suggest that assessing nigrostriatal dopaminergic function with 18F-fluorodopa PET may be a useful diagnostic aid in cases of dementia with Lewy bodies while patients are alive.

AB - Using 18F-fluorodopa PET and a constant 0.0062 influx rate in the putamen, dementia with Lewy bodies (n = 7) was distinguished from AD (n = 10) with a sensitivity of 86% and a specificity of 100%. A constant 0.0071 influx rate in the caudate yielded a sensitivity of 71% and a specificity of 100% for distinction of the two disorders. Despite a limited sample size, these findings suggest that assessing nigrostriatal dopaminergic function with 18F-fluorodopa PET may be a useful diagnostic aid in cases of dementia with Lewy bodies while patients are alive.

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¹⁸F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies

Abstract

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