[18F]FDG mouse brain PET imaging: Absolute quantification of regional cerebral glucose utilization as compared with 2-[14C]DG autoradiography

Hiroshi Toyama; Masanori Ichise; Jeih San Liow; Kendra J. Modell; Douglass C. Vines; Sami Zoghbi; Takanori Esaki; Michelle Cook; Jurgen Seidel; Kazuhiro Katada; Louis Sokoloff; Michael V. Green; Robert B. Innis

doi:10.1016/j.ics.2004.03.022

[¹⁸F]FDG mouse brain PET imaging: Absolute quantification of regional cerebral glucose utilization as compared with 2-[¹⁴C]DG autoradiography

Hiroshi Toyama, Masanori Ichise, Jeih San Liow, Kendra J. Modell, Douglass C. Vines, Sami Zoghbi, Takanori Esaki, Michelle Cook, Jurgen Seidel, Kazuhiro Katada, Louis Sokoloff, Michael V. Green, Robert B. Innis

Radiology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the feasibility of absolute quantification of regional cerebral glucose utilization (rCMR_glc) in mice with ¹⁸FDG PET. To evaluate its use as a gold standard, rCMR_glc was also measured simultaneously with the autoradiographic 2-[¹⁴C]DG method. Serial arterial samples were drawn over 45 min to determine plasma tracer time activities and glucose concentrations. Animals were euthanized at 45 min followed first by brain PET imaging for 15 min and then by brain 2-[¹⁴C]DG autoradiography. Average ¹⁸FDG rCMR_glc values in the cerebral cortex were generally lower (by 8.3%), but strongly correlated with those of 2-[¹⁴C]DG (r²=0.95). The present PET imaging technique allows accurate absolute quantification of rCMR_glc in mice within the limits of the resolution possible with PET.

Original language	English
Pages (from-to)	255-261
Number of pages	7
Journal	International Congress Series
Volume	1265
Issue number	C
DOIs	https://doi.org/10.1016/j.ics.2004.03.022
Publication status	Published - 01-08-2004

All Science Journal Classification (ASJC) codes

General Medicine

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Toyama, H., Ichise, M., Liow, J. S., Modell, K. J., Vines, D. C., Zoghbi, S., Esaki, T., Cook, M., Seidel, J., Katada, K., Sokoloff, L., Green, M. V., & Innis, R. B. (2004). [¹⁸F]FDG mouse brain PET imaging: Absolute quantification of regional cerebral glucose utilization as compared with 2-[¹⁴C]DG autoradiography. International Congress Series, 1265(C), 255-261. https://doi.org/10.1016/j.ics.2004.03.022

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title = "[18F]FDG mouse brain PET imaging: Absolute quantification of regional cerebral glucose utilization as compared with 2-[14C]DG autoradiography",

abstract = "The purpose of this study was to evaluate the feasibility of absolute quantification of regional cerebral glucose utilization (rCMRglc) in mice with 18FDG PET. To evaluate its use as a gold standard, rCMRglc was also measured simultaneously with the autoradiographic 2-[14C]DG method. Serial arterial samples were drawn over 45 min to determine plasma tracer time activities and glucose concentrations. Animals were euthanized at 45 min followed first by brain PET imaging for 15 min and then by brain 2-[14C]DG autoradiography. Average 18FDG rCMRglc values in the cerebral cortex were generally lower (by 8.3%), but strongly correlated with those of 2-[14C]DG (r2=0.95). The present PET imaging technique allows accurate absolute quantification of rCMRglc in mice within the limits of the resolution possible with PET.",

author = "Hiroshi Toyama and Masanori Ichise and Liow, {Jeih San} and Modell, {Kendra J.} and Vines, {Douglass C.} and Sami Zoghbi and Takanori Esaki and Michelle Cook and Jurgen Seidel and Kazuhiro Katada and Louis Sokoloff and Green, {Michael V.} and Innis, {Robert B.}",

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Toyama, H, Ichise, M, Liow, JS, Modell, KJ, Vines, DC, Zoghbi, S, Esaki, T, Cook, M, Seidel, J, Katada, K, Sokoloff, L, Green, MV & Innis, RB 2004, '[¹⁸F]FDG mouse brain PET imaging: Absolute quantification of regional cerebral glucose utilization as compared with 2-[¹⁴C]DG autoradiography', International Congress Series, vol. 1265, no. C, pp. 255-261. https://doi.org/10.1016/j.ics.2004.03.022

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AU - Toyama, Hiroshi

AU - Ichise, Masanori

AU - Liow, Jeih San

AU - Modell, Kendra J.

AU - Vines, Douglass C.

AU - Zoghbi, Sami

AU - Esaki, Takanori

AU - Cook, Michelle

AU - Seidel, Jurgen

AU - Katada, Kazuhiro

AU - Sokoloff, Louis

AU - Green, Michael V.

AU - Innis, Robert B.

PY - 2004/8/1

Y1 - 2004/8/1

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AB - The purpose of this study was to evaluate the feasibility of absolute quantification of regional cerebral glucose utilization (rCMRglc) in mice with 18FDG PET. To evaluate its use as a gold standard, rCMRglc was also measured simultaneously with the autoradiographic 2-[14C]DG method. Serial arterial samples were drawn over 45 min to determine plasma tracer time activities and glucose concentrations. Animals were euthanized at 45 min followed first by brain PET imaging for 15 min and then by brain 2-[14C]DG autoradiography. Average 18FDG rCMRglc values in the cerebral cortex were generally lower (by 8.3%), but strongly correlated with those of 2-[14C]DG (r2=0.95). The present PET imaging technique allows accurate absolute quantification of rCMRglc in mice within the limits of the resolution possible with PET.

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[¹⁸F]FDG mouse brain PET imaging: Absolute quantification of regional cerebral glucose utilization as compared with 2-[¹⁴C]DG autoradiography

Abstract

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