Suppression of hepatitis C virus replicon by TGF-β

Takayuki Murata, Takayuki Ohshima, Masashi Yamaji, Masahiro Hosaka, Yusuke Miyanari, Makoto Hijikata, Kunitada Shimotohno

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51 Citations (Scopus)

Abstract

Hepatitis C virus (HCV) is one of the major causative agents of liver diseases, such as liver inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma. Using an efficient HCV subgenomic replicon system, we demonstrate that transforming growth factor-beta (TGF-β) suppresses viral RNA replication and protein expression from the HCV replicon. We further show that the anti-viral effect of this cytokine is associated with cellular growth arrest in a manner dependent on Smad signaling, not mitogen-activated protein kinase (MAPK) signaling. These results suggest a novel insight into the mechanisms of liver diseases caused by HCV.

Original languageEnglish
Pages (from-to)407-417
Number of pages11
JournalVirology
Volume331
Issue number2
DOIs
Publication statusPublished - 20-01-2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Virology

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  • Cite this

    Murata, T., Ohshima, T., Yamaji, M., Hosaka, M., Miyanari, Y., Hijikata, M., & Shimotohno, K. (2005). Suppression of hepatitis C virus replicon by TGF-β. Virology, 331(2), 407-417. https://doi.org/10.1016/j.virol.2004.10.036