Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside.

Masahiro Ikejiri, Takayuki Ohshima, Keizo Kato, Masaaki Toyama, Takayuki Murata, Kunitada Shimotohno, Tokumi Maruyama

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A series of nucleoside analogues whose 5'-hydroxyl groups are masked by various protective groups were synthesized and evaluated to develop novel anti- hepatitis C virus (HCV) agents. Among the several analogues that showed anti-HCV potency, a 5'-O-benzoyl-2'-deoxyribonucleoside analogue exhibited high anti-HCV activity with an EC(50) of 6.1 microM.

Original languageEnglish
Pages (from-to)439-440
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number51
Publication statusPublished - 01-01-2007

Fingerprint

Virus Replication
Hepacivirus
Deoxyribonucleosides
Nucleosides
Hydroxyl Radical
6-chloropurine-2'-deoxyriboside

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ikejiri, Masahiro ; Ohshima, Takayuki ; Kato, Keizo ; Toyama, Masaaki ; Murata, Takayuki ; Shimotohno, Kunitada ; Maruyama, Tokumi. / Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside. In: Nucleic acids symposium series (2004). 2007 ; No. 51. pp. 439-440.
@article{447bd8d795c44552b0cbb848983873da,
title = "Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside.",
abstract = "A series of nucleoside analogues whose 5'-hydroxyl groups are masked by various protective groups were synthesized and evaluated to develop novel anti- hepatitis C virus (HCV) agents. Among the several analogues that showed anti-HCV potency, a 5'-O-benzoyl-2'-deoxyribonucleoside analogue exhibited high anti-HCV activity with an EC(50) of 6.1 microM.",
author = "Masahiro Ikejiri and Takayuki Ohshima and Keizo Kato and Masaaki Toyama and Takayuki Murata and Kunitada Shimotohno and Tokumi Maruyama",
year = "2007",
month = "1",
day = "1",
language = "English",
pages = "439--440",
journal = "Nucleic acids symposium series (2004)",
issn = "1746-8272",
publisher = "Oxford University Press",
number = "51",

}

Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside. / Ikejiri, Masahiro; Ohshima, Takayuki; Kato, Keizo; Toyama, Masaaki; Murata, Takayuki; Shimotohno, Kunitada; Maruyama, Tokumi.

In: Nucleic acids symposium series (2004), No. 51, 01.01.2007, p. 439-440.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside.

AU - Ikejiri, Masahiro

AU - Ohshima, Takayuki

AU - Kato, Keizo

AU - Toyama, Masaaki

AU - Murata, Takayuki

AU - Shimotohno, Kunitada

AU - Maruyama, Tokumi

PY - 2007/1/1

Y1 - 2007/1/1

N2 - A series of nucleoside analogues whose 5'-hydroxyl groups are masked by various protective groups were synthesized and evaluated to develop novel anti- hepatitis C virus (HCV) agents. Among the several analogues that showed anti-HCV potency, a 5'-O-benzoyl-2'-deoxyribonucleoside analogue exhibited high anti-HCV activity with an EC(50) of 6.1 microM.

AB - A series of nucleoside analogues whose 5'-hydroxyl groups are masked by various protective groups were synthesized and evaluated to develop novel anti- hepatitis C virus (HCV) agents. Among the several analogues that showed anti-HCV potency, a 5'-O-benzoyl-2'-deoxyribonucleoside analogue exhibited high anti-HCV activity with an EC(50) of 6.1 microM.

UR - http://www.scopus.com/inward/record.url?scp=42949142164&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42949142164&partnerID=8YFLogxK

M3 - Article

C2 - 18029775

AN - SCOPUS:42949142164

SP - 439

EP - 440

JO - Nucleic acids symposium series (2004)

JF - Nucleic acids symposium series (2004)

SN - 1746-8272

IS - 51

ER -