Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside.

Masahiro Ikejiri; Takayuki Ohshima; Keizo Kato; Masaaki Toyama; Takayuki Murata; Kunitada Shimotohno; Tokumi Maruyama

doi:10.1093/nass/nrm220

Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside.

Masahiro Ikejiri, Takayuki Ohshima, Keizo Kato, Masaaki Toyama, Takayuki Murata, Kunitada Shimotohno, Tokumi Maruyama

Research output: Contribution to journal › Article › peer-review

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Abstract

A series of nucleoside analogues whose 5'-hydroxyl groups are masked by various protective groups were synthesized and evaluated to develop novel anti- hepatitis C virus (HCV) agents. Among the several analogues that showed anti-HCV potency, a 5'-O-benzoyl-2'-deoxyribonucleoside analogue exhibited high anti-HCV activity with an EC(50) of 6.1 microM.

Original language	English
Pages (from-to)	439-440
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	51
DOIs	https://doi.org/10.1093/nass/nrm220
Publication status	Published - 2007
Externally published	Yes

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General Medicine

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/nass/nrm220

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title = "Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside.",

abstract = "A series of nucleoside analogues whose 5'-hydroxyl groups are masked by various protective groups were synthesized and evaluated to develop novel anti- hepatitis C virus (HCV) agents. Among the several analogues that showed anti-HCV potency, a 5'-O-benzoyl-2'-deoxyribonucleoside analogue exhibited high anti-HCV activity with an EC(50) of 6.1 microM.",

author = "Masahiro Ikejiri and Takayuki Ohshima and Keizo Kato and Masaaki Toyama and Takayuki Murata and Kunitada Shimotohno and Tokumi Maruyama",

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language = "English",

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T1 - Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside.

AU - Ikejiri, Masahiro

AU - Ohshima, Takayuki

AU - Kato, Keizo

AU - Toyama, Masaaki

AU - Murata, Takayuki

AU - Shimotohno, Kunitada

AU - Maruyama, Tokumi

N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

PY - 2007

Y1 - 2007

N2 - A series of nucleoside analogues whose 5'-hydroxyl groups are masked by various protective groups were synthesized and evaluated to develop novel anti- hepatitis C virus (HCV) agents. Among the several analogues that showed anti-HCV potency, a 5'-O-benzoyl-2'-deoxyribonucleoside analogue exhibited high anti-HCV activity with an EC(50) of 6.1 microM.

AB - A series of nucleoside analogues whose 5'-hydroxyl groups are masked by various protective groups were synthesized and evaluated to develop novel anti- hepatitis C virus (HCV) agents. Among the several analogues that showed anti-HCV potency, a 5'-O-benzoyl-2'-deoxyribonucleoside analogue exhibited high anti-HCV activity with an EC(50) of 6.1 microM.

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DO - 10.1093/nass/nrm220

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JO - Nucleic acids symposium series (2004)

JF - Nucleic acids symposium series (2004)

IS - 51

ER -

Suppression of subgenomic hepatitis C virus replication by 5'-O-masked analogues of 6-chloropurine-2'-deoxyriboside.

Abstract

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