A series of nucleoside analogues whose 5'-hydroxyl groups are masked by various protective groups were synthesized and evaluated to develop novel anti- hepatitis C virus (HCV) agents. Among the several analogues that showed anti-HCV potency, a 5'-O-benzoyl-2'-deoxyribonucleoside analogue exhibited high anti-HCV activity with an EC(50) of 6.1 microM.
|Number of pages||2|
|Journal||Nucleic acids symposium series (2004)|
|Publication status||Published - 01-01-2007|
All Science Journal Classification (ASJC) codes