Suppressive effects of linoleic acid on neutrophil oxygen metabolism and phagocytosis

Hirohiko Akamatsu, Jinro Komura, Yoshiki Miyachi, Yasuo Asada, Yukie Niwa

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


On the basis of recent reports that the proportion of linoleic acid (C18:2Cis 9,12), a free fatty acid, is markedly decreased in acne comedones and that tetracycline is effective against acne comedones by acting directly as an antioxidant on infiltrating neutrophils, we investigated the effect of linoleic acid on several inflammatory parameters of neutrophils, including neutrophil chemotaxis, phagocytosis, and generation of reactive oxygen species (ROS). Linoleic acid significantly decreased phagocytosis and the generation of O2-, H2O2, and OH · by neutrophils, whereas it did not significantly inhibit neutrophil chemotaxis or decrease the ROS levels generated in a cell-free, xanthine-xanthine oxidase system. The present study seems to suggest that decreased levels of linoleic acid in acne comedones contribute, in part, to the worsening of acne inflammation by the failure of low levels of linoleic acid to suppress neutrophil phagocytosis and ROS generation.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalJournal of Investigative Dermatology
Issue number3
Publication statusPublished - 09-1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology


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