Suppressive rod-cone interaction in complete and incomplete congential stationary night blindness

N. Tomida, M. Horiguchi, Y. Miyake

Research output: Contribution to journalArticle

Abstract

Dark-adapted rods have a suppressive effect on cone response (suppressive rod-cone interaction: SRCI). This phenomenon has been applied to analyze the pathological mechanism of congenital stationary night blindness (CSNB), but the results have been discrepant among the investigators. Alexander et al reported that 2 individuals with CSNB exhibited a normal SRCI, but Arden and Hogg reported an absence of SRCI in 4 cases of CSNB. We evaluated SRCI in complete and incomplete CSNB. SRCI was tested by measuring luminance threshold for flicker detection (685nm, 1.7 in diameter, 20Hz) across the horizontal meridian of the visual field without and with full-field background illumination. In twelve normal subjects, a reduction of the flicker threshold was observed during presentation of the background. Five cases with complete CSNB showed normal SRCI, but in one case we failed to detect SRCI except at one tested locus. Similarly 5 cases of incomplete CSNB showed normal SRCI, but in one case we failed to detect SRCI except at one tested locus. These results may indicate that SRCI is normal in both complete and incomplete CSNB, but in some cases, SRCI is absent because of localized retinal dysfunction.

Original languageEnglish
Pages (from-to)932-937
Number of pages6
JournalJournal of Japanese Ophthalmological Society
Volume99
Issue number8
Publication statusPublished - 01-01-1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Fingerprint Dive into the research topics of 'Suppressive rod-cone interaction in complete and incomplete congential stationary night blindness'. Together they form a unique fingerprint.

  • Cite this