Survival of macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking in patients with type 2 diabetes

BioBank Japan cohort

BioBank Japan Cooperative Hospital Group

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

BACKGROUND: The number of patients with diabetes is increasing worldwide. Macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking frequently accompany type 2 diabetes. Few data are available related to mortality of Asians with diabetes associated with these serious comorbidities. The present study aimed to quantify the excess mortality risks of type 2 diabetic patients with comorbidities.

METHODS: We analysed the available records of 30,834 Japanese patients with type 2 diabetes from the BioBank Japan Project between 2003 and 2007. Men and women were followed up for median 8.03 and 8.30 years, respectively. We applied Cox proportional hazard model and Kaplan-Meier estimates for survival curves to evaluate mortality in diabetic patients with or without macrovascular disease, chronic respiratory disease, chronic kidney disease, cancer and smoking.

RESULTS: Adjusted hazard ratios (HRs) for mortality were 1.39 (95% CI, 1.09-1.78) for male sex, 2.01 (95% CI, 1.78-2.26) per 10-year increment of age. Adjusted HRs of primary interest were 1.77 (95% CI, 1.42-2.22), macrovascular disease; 1.58 (95% CI, 1.08-2.31), chronic respiratory disease; 2.03 (95% CI, 1.67-2.47), chronic kidney disease; 1.16 (95% CI, 0.86-1.56), cancer; and 1.74 (95% CI, 1.30-2.31), current smoking.

CONCLUSIONS: Diabetic patients with a past or current history of chronic kidney, macrovascular or respiratory diseases or smoking habit have exhibited the highest risk of mortality. Data were limited to those of survivors of comorbidities but we propose the need to improve comorbidities and terminate cigarette smoking for better prognosis in patients with diabetes.

Original languageEnglish
Pages (from-to)S98-S106
JournalJournal of Epidemiology
Volume27
Issue number3
DOIs
Publication statusPublished - 01-03-2017
Externally publishedYes

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Chronic Renal Insufficiency
Type 2 Diabetes Mellitus
Japan
Chronic Disease
Smoking
Survival
Comorbidity
Mortality
Neoplasms
Kaplan-Meier Estimate
Kidney Neoplasms
Proportional Hazards Models
Habits
Survivors
Kidney

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

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title = "Survival of macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking in patients with type 2 diabetes: BioBank Japan cohort",
abstract = "BACKGROUND: The number of patients with diabetes is increasing worldwide. Macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking frequently accompany type 2 diabetes. Few data are available related to mortality of Asians with diabetes associated with these serious comorbidities. The present study aimed to quantify the excess mortality risks of type 2 diabetic patients with comorbidities.METHODS: We analysed the available records of 30,834 Japanese patients with type 2 diabetes from the BioBank Japan Project between 2003 and 2007. Men and women were followed up for median 8.03 and 8.30 years, respectively. We applied Cox proportional hazard model and Kaplan-Meier estimates for survival curves to evaluate mortality in diabetic patients with or without macrovascular disease, chronic respiratory disease, chronic kidney disease, cancer and smoking.RESULTS: Adjusted hazard ratios (HRs) for mortality were 1.39 (95{\%} CI, 1.09-1.78) for male sex, 2.01 (95{\%} CI, 1.78-2.26) per 10-year increment of age. Adjusted HRs of primary interest were 1.77 (95{\%} CI, 1.42-2.22), macrovascular disease; 1.58 (95{\%} CI, 1.08-2.31), chronic respiratory disease; 2.03 (95{\%} CI, 1.67-2.47), chronic kidney disease; 1.16 (95{\%} CI, 0.86-1.56), cancer; and 1.74 (95{\%} CI, 1.30-2.31), current smoking.CONCLUSIONS: Diabetic patients with a past or current history of chronic kidney, macrovascular or respiratory diseases or smoking habit have exhibited the highest risk of mortality. Data were limited to those of survivors of comorbidities but we propose the need to improve comorbidities and terminate cigarette smoking for better prognosis in patients with diabetes.",
author = "{BioBank Japan Cooperative Hospital Group} and Hiroshi Yokomichi and Akiko Nagai and Makoto Hirata and Yutaka Kiyohara and Kaori Muto and Toshiharu Ninomiya and Koichi Matsuda and Yoichiro Kamatani and Akiko Tamakoshi and Michiaki Kubo and Yusuke Nakamura and Zentaro Yamagata",
year = "2017",
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language = "English",
volume = "27",
pages = "S98--S106",
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Survival of macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking in patients with type 2 diabetes : BioBank Japan cohort. / BioBank Japan Cooperative Hospital Group.

In: Journal of Epidemiology, Vol. 27, No. 3, 01.03.2017, p. S98-S106.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Survival of macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking in patients with type 2 diabetes

T2 - BioBank Japan cohort

AU - BioBank Japan Cooperative Hospital Group

AU - Yokomichi, Hiroshi

AU - Nagai, Akiko

AU - Hirata, Makoto

AU - Kiyohara, Yutaka

AU - Muto, Kaori

AU - Ninomiya, Toshiharu

AU - Matsuda, Koichi

AU - Kamatani, Yoichiro

AU - Tamakoshi, Akiko

AU - Kubo, Michiaki

AU - Nakamura, Yusuke

AU - Yamagata, Zentaro

PY - 2017/3/1

Y1 - 2017/3/1

N2 - BACKGROUND: The number of patients with diabetes is increasing worldwide. Macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking frequently accompany type 2 diabetes. Few data are available related to mortality of Asians with diabetes associated with these serious comorbidities. The present study aimed to quantify the excess mortality risks of type 2 diabetic patients with comorbidities.METHODS: We analysed the available records of 30,834 Japanese patients with type 2 diabetes from the BioBank Japan Project between 2003 and 2007. Men and women were followed up for median 8.03 and 8.30 years, respectively. We applied Cox proportional hazard model and Kaplan-Meier estimates for survival curves to evaluate mortality in diabetic patients with or without macrovascular disease, chronic respiratory disease, chronic kidney disease, cancer and smoking.RESULTS: Adjusted hazard ratios (HRs) for mortality were 1.39 (95% CI, 1.09-1.78) for male sex, 2.01 (95% CI, 1.78-2.26) per 10-year increment of age. Adjusted HRs of primary interest were 1.77 (95% CI, 1.42-2.22), macrovascular disease; 1.58 (95% CI, 1.08-2.31), chronic respiratory disease; 2.03 (95% CI, 1.67-2.47), chronic kidney disease; 1.16 (95% CI, 0.86-1.56), cancer; and 1.74 (95% CI, 1.30-2.31), current smoking.CONCLUSIONS: Diabetic patients with a past or current history of chronic kidney, macrovascular or respiratory diseases or smoking habit have exhibited the highest risk of mortality. Data were limited to those of survivors of comorbidities but we propose the need to improve comorbidities and terminate cigarette smoking for better prognosis in patients with diabetes.

AB - BACKGROUND: The number of patients with diabetes is increasing worldwide. Macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking frequently accompany type 2 diabetes. Few data are available related to mortality of Asians with diabetes associated with these serious comorbidities. The present study aimed to quantify the excess mortality risks of type 2 diabetic patients with comorbidities.METHODS: We analysed the available records of 30,834 Japanese patients with type 2 diabetes from the BioBank Japan Project between 2003 and 2007. Men and women were followed up for median 8.03 and 8.30 years, respectively. We applied Cox proportional hazard model and Kaplan-Meier estimates for survival curves to evaluate mortality in diabetic patients with or without macrovascular disease, chronic respiratory disease, chronic kidney disease, cancer and smoking.RESULTS: Adjusted hazard ratios (HRs) for mortality were 1.39 (95% CI, 1.09-1.78) for male sex, 2.01 (95% CI, 1.78-2.26) per 10-year increment of age. Adjusted HRs of primary interest were 1.77 (95% CI, 1.42-2.22), macrovascular disease; 1.58 (95% CI, 1.08-2.31), chronic respiratory disease; 2.03 (95% CI, 1.67-2.47), chronic kidney disease; 1.16 (95% CI, 0.86-1.56), cancer; and 1.74 (95% CI, 1.30-2.31), current smoking.CONCLUSIONS: Diabetic patients with a past or current history of chronic kidney, macrovascular or respiratory diseases or smoking habit have exhibited the highest risk of mortality. Data were limited to those of survivors of comorbidities but we propose the need to improve comorbidities and terminate cigarette smoking for better prognosis in patients with diabetes.

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DO - 10.1016/j.je.2016.12.012

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JO - Journal of Epidemiology

JF - Journal of Epidemiology

SN - 0917-5040

IS - 3

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