Susceptibility of clinically isolated strains of bacteria to carbapenem- related antibiotics

S. Sugiura, H. Umeda, K. Inagaki, Toshitaka Nabeshima

Research output: Contribution to journalArticle

Abstract

The susceptibility of clinically isolated strains of bacteria to carbapenem-related antibiotics, such as panipenem (PAPM), meropenem (MEPM), and imipenem (IPM), was evaluated according to the Kirby-Bauer method (KB method); the selection criteria for these antibiotics were thus examined. There was no difference in the susceptibility rate of four bacteria, E. coli, MSSA, MRSA, and S. epidermidis to PAPM, MEPM and IPM. The sensitivity of P. aeruginosa to the three drugs was MEPM = IMP > PAPM. Enterococcus had low drug susceptibility (17.1%) to MEPM, moderate drug susceptibility (51.2%) to PAPM, and high susceptibility (82.9%) to IPM. The susceptibility of Enterococcus was IPM > PAPM > MEPM. Probable cross-resistance among the three antibiotics was suggested to E. coli, MRSA, S. epidermidis, P. aeruginosa and Enterococcus. The three carbapenem-related antibiotics examined showed no differences in their susceptibility to E. coli, MSSA and S. epidermidis. For drug selection, pharmacokinetics and other factors should be taken into account for these clinically isolated bacteria. Since these three drugs are not indicated for MRSA, it was considered desirable to select MEPM or IPM against P. aeruginosa, and PAPM or IPM for Enterococcus.

Original languageEnglish
Pages (from-to)115-123
Number of pages9
JournalJournal of Applied Therapeutic Research
Volume2
Issue number2
Publication statusPublished - 01-12-1998
Externally publishedYes

Fingerprint

Carbapenems
Imipenem
Enterococcus
Bacteria
Methicillin-Resistant Staphylococcus aureus
Pharmaceutical Preparations
meropenem
Escherichia coli
Anti-Bacterial Agents
Inosine Monophosphate
Patient Selection
panipenem
Pharmacokinetics

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

@article{0fe64b1e97094985ba66b982311e275b,
title = "Susceptibility of clinically isolated strains of bacteria to carbapenem- related antibiotics",
abstract = "The susceptibility of clinically isolated strains of bacteria to carbapenem-related antibiotics, such as panipenem (PAPM), meropenem (MEPM), and imipenem (IPM), was evaluated according to the Kirby-Bauer method (KB method); the selection criteria for these antibiotics were thus examined. There was no difference in the susceptibility rate of four bacteria, E. coli, MSSA, MRSA, and S. epidermidis to PAPM, MEPM and IPM. The sensitivity of P. aeruginosa to the three drugs was MEPM = IMP > PAPM. Enterococcus had low drug susceptibility (17.1{\%}) to MEPM, moderate drug susceptibility (51.2{\%}) to PAPM, and high susceptibility (82.9{\%}) to IPM. The susceptibility of Enterococcus was IPM > PAPM > MEPM. Probable cross-resistance among the three antibiotics was suggested to E. coli, MRSA, S. epidermidis, P. aeruginosa and Enterococcus. The three carbapenem-related antibiotics examined showed no differences in their susceptibility to E. coli, MSSA and S. epidermidis. For drug selection, pharmacokinetics and other factors should be taken into account for these clinically isolated bacteria. Since these three drugs are not indicated for MRSA, it was considered desirable to select MEPM or IPM against P. aeruginosa, and PAPM or IPM for Enterococcus.",
author = "S. Sugiura and H. Umeda and K. Inagaki and Toshitaka Nabeshima",
year = "1998",
month = "12",
day = "1",
language = "English",
volume = "2",
pages = "115--123",
journal = "Journal of Applied Therapeutic Research",
issn = "1029-2659",
publisher = "Euromed Communications",
number = "2",

}

Susceptibility of clinically isolated strains of bacteria to carbapenem- related antibiotics. / Sugiura, S.; Umeda, H.; Inagaki, K.; Nabeshima, Toshitaka.

In: Journal of Applied Therapeutic Research, Vol. 2, No. 2, 01.12.1998, p. 115-123.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Susceptibility of clinically isolated strains of bacteria to carbapenem- related antibiotics

AU - Sugiura, S.

AU - Umeda, H.

AU - Inagaki, K.

AU - Nabeshima, Toshitaka

PY - 1998/12/1

Y1 - 1998/12/1

N2 - The susceptibility of clinically isolated strains of bacteria to carbapenem-related antibiotics, such as panipenem (PAPM), meropenem (MEPM), and imipenem (IPM), was evaluated according to the Kirby-Bauer method (KB method); the selection criteria for these antibiotics were thus examined. There was no difference in the susceptibility rate of four bacteria, E. coli, MSSA, MRSA, and S. epidermidis to PAPM, MEPM and IPM. The sensitivity of P. aeruginosa to the three drugs was MEPM = IMP > PAPM. Enterococcus had low drug susceptibility (17.1%) to MEPM, moderate drug susceptibility (51.2%) to PAPM, and high susceptibility (82.9%) to IPM. The susceptibility of Enterococcus was IPM > PAPM > MEPM. Probable cross-resistance among the three antibiotics was suggested to E. coli, MRSA, S. epidermidis, P. aeruginosa and Enterococcus. The three carbapenem-related antibiotics examined showed no differences in their susceptibility to E. coli, MSSA and S. epidermidis. For drug selection, pharmacokinetics and other factors should be taken into account for these clinically isolated bacteria. Since these three drugs are not indicated for MRSA, it was considered desirable to select MEPM or IPM against P. aeruginosa, and PAPM or IPM for Enterococcus.

AB - The susceptibility of clinically isolated strains of bacteria to carbapenem-related antibiotics, such as panipenem (PAPM), meropenem (MEPM), and imipenem (IPM), was evaluated according to the Kirby-Bauer method (KB method); the selection criteria for these antibiotics were thus examined. There was no difference in the susceptibility rate of four bacteria, E. coli, MSSA, MRSA, and S. epidermidis to PAPM, MEPM and IPM. The sensitivity of P. aeruginosa to the three drugs was MEPM = IMP > PAPM. Enterococcus had low drug susceptibility (17.1%) to MEPM, moderate drug susceptibility (51.2%) to PAPM, and high susceptibility (82.9%) to IPM. The susceptibility of Enterococcus was IPM > PAPM > MEPM. Probable cross-resistance among the three antibiotics was suggested to E. coli, MRSA, S. epidermidis, P. aeruginosa and Enterococcus. The three carbapenem-related antibiotics examined showed no differences in their susceptibility to E. coli, MSSA and S. epidermidis. For drug selection, pharmacokinetics and other factors should be taken into account for these clinically isolated bacteria. Since these three drugs are not indicated for MRSA, it was considered desirable to select MEPM or IPM against P. aeruginosa, and PAPM or IPM for Enterococcus.

UR - http://www.scopus.com/inward/record.url?scp=0032433775&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032433775&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0032433775

VL - 2

SP - 115

EP - 123

JO - Journal of Applied Therapeutic Research

JF - Journal of Applied Therapeutic Research

SN - 1029-2659

IS - 2

ER -