Abstract
The increase in multidrug-resistant Gram-negative bacterial infections has forced the reintroduction of antibiotics such as colistin. However, the spread of the plasmid-borne mcr-1 colistin resistance gene have moved us closer to an era of untreatable Gram-negative infections. To evaluate whether predatory bacteria could be used as a potential therapeutic to treat this upcoming threat, the ability of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus to prey on several clinically relevant mcr-1-positive, colistin-resistant isolates was evaluated. No change in the ability of the predators to prey on free swimming and biofilms of prey cells harboring mcr-1 was measured, as compared to their mcr-1 negative strain.
| Original language | English |
|---|---|
| Pages (from-to) | 52-55 |
| Number of pages | 4 |
| Journal | Research in Microbiology |
| Volume | 169 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 01-01-2018 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Microbiology
- Molecular Biology
Cite this
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Susceptibility of colistin-resistant pathogens to predatory bacteria. / Dharani, Sonal; Kim, Dong Hyun; Shanks, Robert M.Q.; Doi, Yohei; Kadouri, Daniel E.
In: Research in Microbiology, Vol. 169, No. 1, 01.01.2018, p. 52-55.Research output: Contribution to journal › Article
TY - JOUR
T1 - Susceptibility of colistin-resistant pathogens to predatory bacteria
AU - Dharani, Sonal
AU - Kim, Dong Hyun
AU - Shanks, Robert M.Q.
AU - Doi, Yohei
AU - Kadouri, Daniel E.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The increase in multidrug-resistant Gram-negative bacterial infections has forced the reintroduction of antibiotics such as colistin. However, the spread of the plasmid-borne mcr-1 colistin resistance gene have moved us closer to an era of untreatable Gram-negative infections. To evaluate whether predatory bacteria could be used as a potential therapeutic to treat this upcoming threat, the ability of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus to prey on several clinically relevant mcr-1-positive, colistin-resistant isolates was evaluated. No change in the ability of the predators to prey on free swimming and biofilms of prey cells harboring mcr-1 was measured, as compared to their mcr-1 negative strain.
AB - The increase in multidrug-resistant Gram-negative bacterial infections has forced the reintroduction of antibiotics such as colistin. However, the spread of the plasmid-borne mcr-1 colistin resistance gene have moved us closer to an era of untreatable Gram-negative infections. To evaluate whether predatory bacteria could be used as a potential therapeutic to treat this upcoming threat, the ability of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus to prey on several clinically relevant mcr-1-positive, colistin-resistant isolates was evaluated. No change in the ability of the predators to prey on free swimming and biofilms of prey cells harboring mcr-1 was measured, as compared to their mcr-1 negative strain.
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UR - http://www.scopus.com/inward/citedby.url?scp=85029909673&partnerID=8YFLogxK
U2 - 10.1016/j.resmic.2017.09.001
DO - 10.1016/j.resmic.2017.09.001
M3 - Article
VL - 169
SP - 52
EP - 55
JO - Research in Microbiology
JF - Research in Microbiology
SN - 0923-2508
IS - 1
ER -