Susceptibility of colistin-resistant pathogens to predatory bacteria

Sonal Dharani, Dong Hyun Kim, Robert M.Q. Shanks, Yohei Doi, Daniel E. Kadouri

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The increase in multidrug-resistant Gram-negative bacterial infections has forced the reintroduction of antibiotics such as colistin. However, the spread of the plasmid-borne mcr-1 colistin resistance gene have moved us closer to an era of untreatable Gram-negative infections. To evaluate whether predatory bacteria could be used as a potential therapeutic to treat this upcoming threat, the ability of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus to prey on several clinically relevant mcr-1-positive, colistin-resistant isolates was evaluated. No change in the ability of the predators to prey on free swimming and biofilms of prey cells harboring mcr-1 was measured, as compared to their mcr-1 negative strain.

Original languageEnglish
Pages (from-to)52-55
Number of pages4
JournalResearch in Microbiology
Volume169
Issue number1
DOIs
Publication statusPublished - 01-01-2018
Externally publishedYes

Fingerprint

Colistin
Bacteria
Gram-Negative Bacterial Infections
Biofilms
Plasmids
Anti-Bacterial Agents
Infection
Genes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology

Cite this

Dharani, Sonal ; Kim, Dong Hyun ; Shanks, Robert M.Q. ; Doi, Yohei ; Kadouri, Daniel E. / Susceptibility of colistin-resistant pathogens to predatory bacteria. In: Research in Microbiology. 2018 ; Vol. 169, No. 1. pp. 52-55.
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Susceptibility of colistin-resistant pathogens to predatory bacteria. / Dharani, Sonal; Kim, Dong Hyun; Shanks, Robert M.Q.; Doi, Yohei; Kadouri, Daniel E.

In: Research in Microbiology, Vol. 169, No. 1, 01.01.2018, p. 52-55.

Research output: Contribution to journalArticle

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