Susceptibility of colistin-resistant pathogens to predatory bacteria

Sonal Dharani, Dong Hyun Kim, Robert M.Q. Shanks, Yohei Doi, Daniel E. Kadouri

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


The increase in multidrug-resistant Gram-negative bacterial infections has forced the reintroduction of antibiotics such as colistin. However, the spread of the plasmid-borne mcr-1 colistin resistance gene have moved us closer to an era of untreatable Gram-negative infections. To evaluate whether predatory bacteria could be used as a potential therapeutic to treat this upcoming threat, the ability of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus to prey on several clinically relevant mcr-1-positive, colistin-resistant isolates was evaluated. No change in the ability of the predators to prey on free swimming and biofilms of prey cells harboring mcr-1 was measured, as compared to their mcr-1 negative strain.

Original languageEnglish
Pages (from-to)52-55
Number of pages4
JournalResearch in Microbiology
Issue number1
Publication statusPublished - 01-2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology


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