Susceptibility of nude mice carrying the Fv-4 gene to friend murine leukemia virus infection

Kyoko Higo, Yoshinao Kubo, Yasumasa Iwatani, Takeshi Ono, Michiyuki Maeda, Hiroshi Hiai, Tohru Masuda, Kagemasa Kuribayashi, Fengmin Zhang, Ta Yar Lamin, Akio Adachi, Akinori Ishimoto

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9 Citations (Scopus)


Fv-4 is a mouse gene that dominantly confers resistance to infection with Friend murine leukemia virus (F-MuLV) (S. Suzuki, Jpn. J. Exp. Med. 45:473-478, 1975). Despite complete resistance to ecotropic MuLV infection in mice carrying the Fv-4 gene, it is known that cells carrying the resistance gene in tissue culture do not always show resistance as extensive as that in vivo (H. Yoshikura and T. Odaka, JNCI 61:461-463, 1978). To investigate the immunological effect on resistance in vivo, we introduced the Fv-4 gene into BALB/c nude mice (Fv-4(-/-) nude(nu/nu)) by mating them with Fv-4 congenic BALB/c mice (Fv-4(r/r) nude(+/+)) and examined the susceptibility of the F2 progeny to F-MuLV. All BALB/c nude mice without the Fv-4 gene (Fv-4(-/-) nude(nu/nu)) were permissive to F-MuLV and developed erythroleukemia within 2 weeks after virus inoculation. The BALB/c nude mice with the Fv-4 gene (Fv- 4(r/r) nude(nu/nu)) did not develop leukemia, and no or little virus was detected in the spleen 7 weeks after virus inoculation. The resistance to F- MuLV was dominant in (Fv-4 congenic BALB/c x BALB/c nude) F1 mice with the Fv-4(r/-) nude(nu/+) genotype as strictly as in (Fv-4 congenic BALB/c x BALB/c) F1 mice with the Fv-4(r/-) nude(+/+) genotype. However, almost all BALB/c nude mice with the Fv-4(r/-) nude(nu/nu) genotype developed the disease within 7 weeks, and the virus was detected in all of their spleens even in the mice without leukemia. These results show that the resistance caused by the Fv-4 gene is recessive in nude mice and dominant in BALB/c mice. Some immunological effects, perhaps cell-mediated immunity, may play important roles in the resistance to F-MuLV infection in vivo in addition to the dosage effect of the Fv-4 product.

Original languageEnglish
Pages (from-to)750-754
Number of pages5
JournalJournal of Virology
Issue number1
Publication statusPublished - 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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