Abstract
Considerable rodent strain differences have been documented with regard to susceptibility to colon carcinogens. To clarify mechanisms, chimeras of susceptible strain C3H and relatively resistant strain C57BL/6N (B6) mice were exposed to a colonotropic carcinogen, 1,2-dimethylhydrazine (DMH) and tumor incidence and multiplicity were assessed. In the chimeras, incidence was as high as the C3H level. Multiplicity of lesions of B6 cells was also increased (P<0.001), but maintenance of the strain difference. When tumor localization was analyzed, tumors of B6 genotype in chimeras demonstrated a greater spread of distribution than in the parental case. The chimeric environment may thus stimulate tumor initiation but cell autonomous suppressive factors may be retained.
Original language | English |
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Pages (from-to) | 205-211 |
Number of pages | 7 |
Journal | Cancer Letters |
Volume | 239 |
Issue number | 2 |
DOIs | |
Publication status | Published - 08-08-2006 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research