Susceptibility to drug-induced seizures of Fyn tyrosine kinase-deficient mice

Tsuyoshi Miyakawa, Takeshi Yagi, Kyoko Tateishi, Hiroaki Niki

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Mice deficient for the fyn gene were examined for their susceptibility to seizures induced by various convulsive drugs, including pentylenetetrazol, picrotoxin, bicuculline, kainic acid, N-methyl-D-aspartate (NMDA) and strychnine. Homozygous mutant (fyn(z)/fyn(z)) mice were significantly more likely to show myoclonic convulsions than were heterozygous mutants (+/fyn(z)) when pentylenetetrazol, picrotoxin, bicuculline, kainic acid and NMDA were administered. On the other hand, no difference in seizure susceptibility was found between homozygous and heterozygous mutants when strychnine was administered. These results provide evidence of abnormal susceptibility to seizures induced by anti-GABAergic agents and agonists for central excitatory amino acids in Fyn-deficient mice.

Original languageEnglish
Pages (from-to)2723-2726
Number of pages4
JournalNeuroreport
Volume7
Issue number15-17
DOIs
Publication statusPublished - 01-01-1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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