Sustained brain-derived neurotrophic factor up-regulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine

Comparison with adult treatment

Makoto Takahashi, Akiyoshi Kakita, Takashi Futamura, Yuichiro Watanabe, Makoto Mizuno, Kenji Sakimura, Eero Castren, Toshitaka Nabeshima, Toshiyuki Someya, Hiroyuki Nawa

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Brain-derived neurotrophic factor (BDNF) is involved in synaptic development and plasticity, and alterations in BDNF expression or signaling are implicated in drug addiction and psychiatric diseases, such as depression and schizophrenia. In this study, we administered phencyclidine to postnatal and adult rats with different time schedules, and determined the correlations between BDNF expression and the behavioral effects. Both single and repeated phencyclidine injections into adult rats induced BDNF up-regulation in the corticolimbic system and a decrease in prepulse inhibition, both of which were transient. In contrast, subchronic postnatal administration increased BDNF protein and mRNA levels in the hippocampus and entorhinal cortex, which were sustained until 8 weeks of age. In parallel, the postnatal rats treated with phencyclidine developed a persistent decrease in prepulse inhibition at the adult stage. The chronic BDNF increase appeared to contribute to the prepulse inhibition abnormality, as subchronic BDNF infusion into the hippocampus of normal rats mimicked the prepulse inhibition deficits. This study suggests that phencyclidine exposure during brain development induces sustained BDNF up-regulation in the limbic system with a biological link to sensorimotor gating deficits.

Original languageEnglish
Pages (from-to)770-780
Number of pages11
JournalJournal of Neurochemistry
Volume99
Issue number3
DOIs
Publication statusPublished - 01-11-2006
Externally publishedYes

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Sensory Gating
Phencyclidine
Brain-Derived Neurotrophic Factor
Up-Regulation
Rats
Therapeutics
Hippocampus
Limbic System
Entorhinal Cortex
Neuronal Plasticity
Nerve Growth Factors
Substance-Related Disorders
Plasticity
Psychiatry
Brain
Schizophrenia
Appointments and Schedules
Depression
Messenger RNA
Injections

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Takahashi, Makoto ; Kakita, Akiyoshi ; Futamura, Takashi ; Watanabe, Yuichiro ; Mizuno, Makoto ; Sakimura, Kenji ; Castren, Eero ; Nabeshima, Toshitaka ; Someya, Toshiyuki ; Nawa, Hiroyuki. / Sustained brain-derived neurotrophic factor up-regulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine : Comparison with adult treatment. In: Journal of Neurochemistry. 2006 ; Vol. 99, No. 3. pp. 770-780.
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Sustained brain-derived neurotrophic factor up-regulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine : Comparison with adult treatment. / Takahashi, Makoto; Kakita, Akiyoshi; Futamura, Takashi; Watanabe, Yuichiro; Mizuno, Makoto; Sakimura, Kenji; Castren, Eero; Nabeshima, Toshitaka; Someya, Toshiyuki; Nawa, Hiroyuki.

In: Journal of Neurochemistry, Vol. 99, No. 3, 01.11.2006, p. 770-780.

Research output: Contribution to journalArticle

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