TY - JOUR
T1 - Synaptic development is controlled in the periactive zones of drosophila synapses
AU - Sone, M.
AU - Suzuki, E.
AU - Hoshino, M.
AU - Hou, D.
AU - Kuromi, H.
AU - Fukata, M.
AU - Kuroda, S.
AU - Kaibuchi, K.
AU - Nabeshima, Y. I.
AU - Hama, C.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - A cell-adhesion molecule fasciclin 2 (FAS2), which is required for synaptic growth and still life (SIF), an activator of RAC, were found to localize in the surrounding region of the active zone, defining the periactive zone in Drosophila neuromuscular synapses. βPS integrin and discs large (DLG), both involved in synaptic development, also decorated the zone. However, shibire (SHI), the Drosophila dynamin that regulates endocytosis, was found in the distinct region. Mutant analyses showed that sif genetically interacted with Fas2 in synaptic growth and that the proper localization of SIF required FAS2, suggesting that they are components in related signaling pathways that locally function in the periactive zones. We propose that neurotransmission and synaptic growth are primarily regulated in segregated subcellular spaces, active zones and periactive zones, respectively.
AB - A cell-adhesion molecule fasciclin 2 (FAS2), which is required for synaptic growth and still life (SIF), an activator of RAC, were found to localize in the surrounding region of the active zone, defining the periactive zone in Drosophila neuromuscular synapses. βPS integrin and discs large (DLG), both involved in synaptic development, also decorated the zone. However, shibire (SHI), the Drosophila dynamin that regulates endocytosis, was found in the distinct region. Mutant analyses showed that sif genetically interacted with Fas2 in synaptic growth and that the proper localization of SIF required FAS2, suggesting that they are components in related signaling pathways that locally function in the periactive zones. We propose that neurotransmission and synaptic growth are primarily regulated in segregated subcellular spaces, active zones and periactive zones, respectively.
UR - http://www.scopus.com/inward/record.url?scp=0033757193&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033757193&partnerID=8YFLogxK
M3 - Article
C2 - 10976048
AN - SCOPUS:0033757193
VL - 127
SP - 4157
EP - 4168
JO - Journal of Embryology and Experimental Morphology
JF - Journal of Embryology and Experimental Morphology
SN - 0950-1991
IS - 19
ER -