TY - JOUR
T1 - Synchronous driver gene alterations (EGFR L858R, T790M, and ROS1) rearrangements in a patient with early-stage lung adenocarcinoma
AU - Masago, Katsuhiro
AU - Kuroda, Hiroaki
AU - Takahashi, Yusuke
AU - Oya, Yuko
AU - Sasaki, Eiichi
AU - Sakakura, Noriaki
AU - Matsushita, Hirokazu
N1 - Publisher Copyright:
© 2022
PY - 2022/11
Y1 - 2022/11
N2 - Concurrent EGFR mutation and ROS1 rearrangement is a rare event in early-stage non-small-cell lung cancer. In addition, a co-occurring de novo EGFR T790M mutation in such a case is extremely rare. We encountered a 72-year-old woman who developed 3 early-stage lung lesions synchronously, one each harboring EGFR L858R, ROS1 rearrangement, and EGFR L858R and de novo T790M. These three nodules were pathologically time-matched lepidic predominant adenocarcinoma with small invasive lesions, which may reflect the concept of field cancerization with driver mutations.
AB - Concurrent EGFR mutation and ROS1 rearrangement is a rare event in early-stage non-small-cell lung cancer. In addition, a co-occurring de novo EGFR T790M mutation in such a case is extremely rare. We encountered a 72-year-old woman who developed 3 early-stage lung lesions synchronously, one each harboring EGFR L858R, ROS1 rearrangement, and EGFR L858R and de novo T790M. These three nodules were pathologically time-matched lepidic predominant adenocarcinoma with small invasive lesions, which may reflect the concept of field cancerization with driver mutations.
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U2 - 10.1016/j.cancergen.2022.09.010
DO - 10.1016/j.cancergen.2022.09.010
M3 - Article
C2 - 36332423
AN - SCOPUS:85142940319
SN - 2210-7762
VL - 268-269
SP - 124
EP - 127
JO - Cancer Genetics
JF - Cancer Genetics
ER -
