Synchronous driver gene alterations (EGFR L858R, T790M, and ROS1) rearrangements in a patient with early-stage lung adenocarcinoma

Katsuhiro Masago; Hiroaki Kuroda; Yusuke Takahashi; Yuko Oya; Eiichi Sasaki; Noriaki Sakakura; Hirokazu Matsushita

doi:10.1016/j.cancergen.2022.09.010

Synchronous driver gene alterations (EGFR L858R, T790M, and ROS1) rearrangements in a patient with early-stage lung adenocarcinoma

Katsuhiro Masago
, Hiroaki Kuroda
, Yusuke Takahashi
, Yuko Oya
, Eiichi Sasaki
, Noriaki Sakakura
, Hirokazu Matsushita

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Concurrent EGFR mutation and ROS1 rearrangement is a rare event in early-stage non-small-cell lung cancer. In addition, a co-occurring de novo EGFR T790M mutation in such a case is extremely rare. We encountered a 72-year-old woman who developed 3 early-stage lung lesions synchronously, one each harboring EGFR L858R, ROS1 rearrangement, and EGFR L858R and de novo T790M. These three nodules were pathologically time-matched lepidic predominant adenocarcinoma with small invasive lesions, which may reflect the concept of field cancerization with driver mutations.

Original language	English
Pages (from-to)	124-127
Number of pages	4
Journal	Cancer Genetics
Volume	268-269
DOIs	https://doi.org/10.1016/j.cancergen.2022.09.010
Publication status	Published - 11-2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics
Cancer Research

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10.1016/j.cancergen.2022.09.010

Cite this

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title = "Synchronous driver gene alterations (EGFR L858R, T790M, and ROS1) rearrangements in a patient with early-stage lung adenocarcinoma",

abstract = "Concurrent EGFR mutation and ROS1 rearrangement is a rare event in early-stage non-small-cell lung cancer. In addition, a co-occurring de novo EGFR T790M mutation in such a case is extremely rare. We encountered a 72-year-old woman who developed 3 early-stage lung lesions synchronously, one each harboring EGFR L858R, ROS1 rearrangement, and EGFR L858R and de novo T790M. These three nodules were pathologically time-matched lepidic predominant adenocarcinoma with small invasive lesions, which may reflect the concept of field cancerization with driver mutations.",

author = "Katsuhiro Masago and Hiroaki Kuroda and Yusuke Takahashi and Yuko Oya and Eiichi Sasaki and Noriaki Sakakura and Hirokazu Matsushita",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = nov,

doi = "10.1016/j.cancergen.2022.09.010",

language = "English",

volume = "268-269",

pages = "124--127",

journal = "Cancer Genetics",

issn = "2210-7762",

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TY - JOUR

T1 - Synchronous driver gene alterations (EGFR L858R, T790M, and ROS1) rearrangements in a patient with early-stage lung adenocarcinoma

AU - Masago, Katsuhiro

AU - Kuroda, Hiroaki

AU - Takahashi, Yusuke

AU - Oya, Yuko

AU - Sasaki, Eiichi

AU - Sakakura, Noriaki

AU - Matsushita, Hirokazu

PY - 2022/11

Y1 - 2022/11

N2 - Concurrent EGFR mutation and ROS1 rearrangement is a rare event in early-stage non-small-cell lung cancer. In addition, a co-occurring de novo EGFR T790M mutation in such a case is extremely rare. We encountered a 72-year-old woman who developed 3 early-stage lung lesions synchronously, one each harboring EGFR L858R, ROS1 rearrangement, and EGFR L858R and de novo T790M. These three nodules were pathologically time-matched lepidic predominant adenocarcinoma with small invasive lesions, which may reflect the concept of field cancerization with driver mutations.

AB - Concurrent EGFR mutation and ROS1 rearrangement is a rare event in early-stage non-small-cell lung cancer. In addition, a co-occurring de novo EGFR T790M mutation in such a case is extremely rare. We encountered a 72-year-old woman who developed 3 early-stage lung lesions synchronously, one each harboring EGFR L858R, ROS1 rearrangement, and EGFR L858R and de novo T790M. These three nodules were pathologically time-matched lepidic predominant adenocarcinoma with small invasive lesions, which may reflect the concept of field cancerization with driver mutations.

UR - https://www.scopus.com/pages/publications/85142940319

UR - https://www.scopus.com/pages/publications/85142940319#tab=citedBy

U2 - 10.1016/j.cancergen.2022.09.010

DO - 10.1016/j.cancergen.2022.09.010

M3 - Article

C2 - 36332423

AN - SCOPUS:85142940319

SN - 2210-7762

VL - 268-269

SP - 124

EP - 127

JO - Cancer Genetics

JF - Cancer Genetics

ER -

Synchronous driver gene alterations (EGFR L858R, T790M, and ROS1) rearrangements in a patient with early-stage lung adenocarcinoma

Abstract

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